Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development-Reference-Cited by-同舟云学术

Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development

Published:2023-07-21 Issue:14 Volume:24 Page:11731
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Furukawa Tatsuhiko¹^ORCID,Mimami Kentaro²,Nagata Toshiyuki³,Yamamoto Masatasu⁴,Sato Masami³,Tanimoto Akihide¹^ORCID

Affiliation:

1. Department of Pathology, Graduate School Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

2. Department of Pharmacy, University of Miyazaki Hospital, 5200 Kihara Kiyotake cho, Miyazaki 889-1692, Japan

3. Department of General Thoracic Surgery, Graduate School Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

4. Department of Molecular Oncology, Graduate School Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

Abstract

The circadian rhythm-related genes BHLHE40/DEC1 and BHLHE41/DEC2 have various functions under different cell and tissue conditions. BHLHE41/DEC2 has been reported to be both a cancer-suppressive and an oncogenic gene during cancer development. The effects of BHLHE41/DEC2 on differentiation have been examined using Bhlhe41/Dec2 knockout mice and/or in vitro differentiation models, and research has been conducted using genetic analysis of tumor cells, in vitro analysis of cancer cell lines, and immunohistochemical studies of the clinical samples. We summarize some of these studies, detail several problems, and consider possible reasons for contradictory results and the needs for further research.

Funder

JSPS KAKENHI

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/14/11731/pdf

Reference52 articles.

1. Dec1 and Dec2 are regulators of the mammalian molecular clock;Honma;Nature,2002

2. The transcriptional repressor DEC2 regulates sleep length in mammals;He;Science,2009

3. A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans;Pellegrino;Sleep,2014

4. DEC2 modulates orexin expression and regulates sleep;Hirano;Proc. Natl. Acad. Sci. USA,2018

5. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment;Yang;Nat. Immunol.,2009