Relationship between Lower Extremity Peripheral Arterial Disease and Mild Cognitive Impairment in Hemodialysis Patients

Author:

Nishimura Akinori1ORCID,Hidaka Sumi23ORCID,Kawaguchi Takayuki4ORCID,Watanabe Aki5ORCID,Mochida Yasuhiro2,Ishioka Kunihiro2ORCID,Mwanatanbwe Milanga67,Ohtake Takayasu23ORCID,Kobayashi Shuzo23

Affiliation:

1. Rehabilitation Unit, Shonan Kamakura General Hospital, Okamoto 1370_1, Kamakura 247-8533, Japan

2. Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura 247-8533, Japan

3. Shonan Research Institute of Innovative Medicine (sRIIM), Kamakura 247-8533, Japan

4. Department of Community Mental Health and Law, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira 187-8553, Japan

5. School of Allied Health Sciences, Kitasato University, Sagamihara 252-0373, Japan

6. Department of Pathology, University of Mbuji-Mayi, Mbuji-Mayi 8010, Democratic Republic of the Congo

7. International Division of Tokushukai of Medical Corporation, Tokushukai, Chiyoda-ku 102-0074, Japan

Abstract

Background: The link between arterial stiffness and mild cognitive impairment (MCI) in patients on hemodialysis (HD) has been receiving increased attention. The purpose of this study was to investigate the relationship between cognitive function and ankle brachial index (ABI) and toe brachial index (TBI) values in patients on hemodialysis. Of the 100 participants (mean age: 67.9 years; average history of hemodialysis: 7.3 years). Of these, 46.0% had MCI. The MoCA-J scores were significantly higher in the ABI ≥ 1.06 group. However, the MoCA-J scores divided into the two groups according to the TBI cutoff value were not significantly different. In a multiple regression model with the MoCA-J scores as the objective variable, the ABI was a significantly associated factor. This study indicates that a low ABI might be associated with MCI.

Publisher

MDPI AG

Subject

General Medicine

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