Affiliation:
1. State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430072, China
2. Department of Endodontics, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
Abstract
Extracellular vesicles, as bioactive molecules, have been extensively studied. There are abundant studies in the literature on their biogenesis, secretion, structure, and content, and their roles in pathophysiological processes. Extracellular vesicles have been reviewed as biomarkers for use in diagnostic tools. Saliva contains many extracellular vesicles, and compared with other body fluids, it is easier to obtain in a non-invasive way, making its acquisition more easily accepted by patients. In recent years, there have been numerous new studies investigating the role of salivary extracellular vesicles as biomarkers. These studies have significant implications for future clinical diagnosis. Therefore, in this paper, we summarize and review the potential applications of salivary extracellular vesicles as biomarkers, and we also describe their other functions (e.g., hemostasis, innate immune defense) in both oral and non-oral diseases.
Funder
International Scientific Collaboration Project of Hubei Province
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference158 articles.
1. SnapShot: Extracellular Vesicles;Cocozza;Cell,2020
2. Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study;Zaborowski;Bioscience,2015
3. Emerging roles of exosomes in normal and pathological conditions: New insights for diagnosis and therapeutic applications;Herschlik;Front. Immunol.,2015
4. Extracellular vesicles: Exosomes, microvesicles, and friends;Raposo;J. Cell Biol.,2013
5. Doyle, L.M., and Wang, M.Z. (2019). Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. Cells, 8.