Development and Characterization of SBA-15 Imprinted Polymers for Spiramycin Analysis

Author:

González-Gómez Lorena12ORCID,Morante-Zarcero Sonia1ORCID,Pérez-Quintanilla Damián1ORCID,González Gema Paniagua2,Garcinuño Rosa M.2,Hernando Pilar Fernández2,Sierra Isabel13ORCID

Affiliation:

1. Departamento de Tecnología Química y Ambiental, Escuela Superior de Ciencias Experimentales y Tecnología (ESCET), Universidad Rey Juan Carlos, C/Tulipán s/n, Móstoles, 28933 Madrid, Spain

2. Departamento de Ciencias Analíticas, Facultad de Ciencias, Universidad Nacional de Educación a Distancia, Las Rozas, 28232 Madrid, Spain

3. Instituto de Tecnologías para la Sostenibilidad, Universidad Rey Juan Carlos, C/Tulipán s/n, Móstoles, 28933 Madrid, Spain

Abstract

This work focuses on the development of a hybrid material based on SBA-15 silica with a molecularly imprinted polymer (MIP), using spiramycin (SPI) as a template, for use as sorbent in solid-phase extraction (SPE). Characterization techniques such as nitrogen gas adsorption–desorption isotherms, infrared spectroscopy and scanning electron microscopy confirmed the structure and properties of the SBA-15@MIP-SPI material. SPE conditions using SBA-15@MIP-SPI as sorbent were optimized, which allowed us to demonstrate the high selectivity and adsorption capacity of SPI on the synthesized material. The best conditions were 50 mg of sorbent, loading with 1 mL of standard solution or sample of cow milk previously extracted in acetonitrile and eluting with 3 mL of methanol with 1% acetic acid. After the optimization process, the material demonstrated recovery percentages of 81 ± 3% in SPI standard solutions and showed its potential in cow milk samples (71 ± 6%). The novelty of the research consists of the combination of MIPs with SBA-15, which could offer important advantages in terms of specific surface area and porous structure, thus improving performance and reducing the amount of sorbent compared to other traditional methods.

Funder

Comunidad of Madrid and European funding from the FSE and FEDER programs

Publisher

MDPI AG

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