Affiliation:
1. Department of Surgery, Chris Hani Baragwaneth Academic Hospital, University of the Witwatersrand, Johannesburg 1864, South Africa
Abstract
Serum procalcitonin (PCT) is a biomarker used to diagnose sepsis and infection. Following invasive bacterial infection, PCT is detectable in peripheral blood. The aim of our study was to determine if there is a relationship between serum PCT post-burn wound debridement and burn-related sepsis. In total, 34 participants were recruited from 1 November 2019 to 31 July 2020. Serum PCT levels were drawn on days 0, 1, 2, and 3, with day 0 being the day of the surgery. Blood culture samples were drawn on days 0 and 3. Statistical analyses were performed using STATA©. Descriptive statistics were presented as the median for continuous data and frequencies for categorical data. A two-sample Wilcoxon–Mann–Whitney test was performed to assess the correlation between the PCT values and blood culture positivity. In all, 33 burn debridement procedures were completed, and 1 patient demised before surgery. The median age was 35.5 years; 61.8% were male. Four patients had comorbidities. There was a trend of higher PCT values from day 0 to day 3. The median PCT on day 0 was 3.30 µg/L (IQR 0.78–15.10), compared to day 3 PCT which was 5.15 µg/L (IQR 1.35–18.55). The median values for serum PCT for days 0 to 3 were above the normal threshold regardless of BC positivity. There was a statistically significant difference in the PCT levels between positive and negative BC, with a p value of 0.0087 for day 3 serum PCT. The findings indicate an association of a high serum PCT level with a positive blood culture in a burn patient post-debridement surgery. A higher numerical threshold/cut-off of serum PCT should be used for this cohort of patients, to aid in the diagnosis of sepsis. A cut-off value could not be determined due to the small sample size.
Funder
Chris Hani Baragwaneth Academic Hospital Adult Burns Unit
Reference27 articles.
1. Yakupu, A., Zhang, J., Dong, W., Song, F., Dong, J., and Lu, S. (2022). The epidemiological characteristic and trends of burns globally. BMC Public Health, 22.
2. Burns in sub-Saharan Africa: A review;Nthumba;Burns,2016
3. Burns in low- and middle-income countries: A review of available literature on descriptive epidemiology, risk factors, treatment, and prevention;Forjuoh;Burns,2006
4. Predicting and managing sepsis in burn patients: Current perspectives;Lopez;Ther. Clin. Risk Manag.,2017
5. Burn wound healing and treatment: Review and advancements;Rowan;Crit. Care,2015