Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis-Reference-Cited by-同舟云学术

Anti-Pulmonary Fibrosis Activities of Triterpenoids from Oenothera biennis

Published:2022-07-29 Issue:15 Volume:27 Page:4870
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Liu Juanjuan,Zhang Jingke,Zeng Mengnan,Li Meng^ORCID,Xie Shuangshuang,Zheng Xiaoke,Feng Weisheng

Abstract

Five new triterpenoids, oenotheralanosterols C-G (1–5), with seven known triterpenoidcompounds, namely 2α,3α,19α-trihydroxy-24-norurs4,12-dien-28-oic acid (6), 3β,23-dihydroxy-1-oxo-olean-12-en-28-oic acid (7), remangilone C (8), knoxivalic acid A (9), termichebulolide (10), rosasecotriterpene A (11), androsanortriterpene C (12), were extracted and separated from the dichloromethane part of Oenothera biennis L. The anti-pulmonary fibrosis activities of all the compounds against TGF-β1-induced damage tonormal human lung epithelial (BEAS-2B) cells were investigated in vitro. The results showed that compounds 1–2, 6, 8, and 11 exhibited significant anti-pulmonary fibrosis activities, with EC50 values ranging from 4.7 μM to 9.9 μM.

Funder

The Major Science and Technology Projects in Henan Province

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/27/15/4870/pdf

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