New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus Talaromyces purpureogenus-Reference-Cited by-全球学者库

New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus Talaromyces purpureogenus

Published:2023-11-18 Issue:22 Volume:28 Page:7650
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Anwar Alaa¹^ORCID,Elnaggar Mohamed S.¹²^ORCID,Elissawy Ahmed M.¹³^ORCID,Ibrahim Nehal¹^ORCID,Mándi Attila⁴^ORCID,Kurtán Tibor⁴^ORCID,Liu Zhen⁵^ORCID,El-Ahmady Sherweit H.¹,Kalscheuer Rainer²^ORCID

Affiliation:

1. Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbassia, Cairo 11566, Egypt

2. Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany

3. Center for Drug Discovery Research and Development, Faculty of Pharmacy, Ain-Shams University, Abbassia, Cairo 11566, Egypt

4. Department of Organic Chemistry, University of Debrecen, P.O. Box 400, 4002 Debrecen, Hungary

5. Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, China

Abstract

In this study, we report the isolation of two new meroterpenoids, miniolutelide D (1) and miniolutelide E (13-epi-miniolutelide C) (2), along with two meroterpenoidal analogues (3 and 4) and two phenolic compounds (5 and 6) from the endophytic fungus Talaromyces purpureogenus derived from Punica granatum fruits. Their structures were elucidated using extensive MS, 1D, and 2D NMR spectroscopic analyses as well as by comparing with data in the literature. The absolute configurations of 1 and 2 were determined using TDDFT-ECD calculations. Antimicrobial activity was evaluated. Compound 5 displayed significant activity against methicillin-resistant Staphylococcus aureus strain ATCC 700699 and moderate activity against S. aureus strain ATCC 29213.

Funder

Ministry of Higher Education of the Arab Republic of Egypt

Center of Drug Discovery, Ain-Shams University

CeMSA@HHU

National Research Development and Innovation Office

Governmental Information Technology Development Agency

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/22/7650/pdf

Reference38 articles.

1. Natural Products as Sources of New Drugs from 1981 to 2014;Newman;J. Nat. Prod.,2016

2. Bogas, A.C., Cruz, F.P.N., Lacava, P.T., and Sousa, C.P. (2022). Endophytic fungi: An overview on biotechnological and agronomic potential. Braz. J. Biol., 84.

3. Endophytic Fungi Inhabiting Medicinal Plants and Their Bioactive Secondary Metabolites;Lee;Nat. Prod. Sci.,2020

4. Gupta, S., Chaturvedi, P., Kulkarni, M.G., and Van Staden, J. (2020). A critical review on exploiting the pharmaceutical potential of plant endophytic fungi. Biotechnol. Adv., 39.

5. An insight into endophytic antimicrobial compounds: An updated analysis;Digra;Plant Biotechnol. Rep.,2023