Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy
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Published:2023-03-17
Issue:6
Volume:28
Page:2738
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Zhang Xinchao1, Chen Siyuan2, Luo Dan3, Chen Dan3, Zhou Hong1ORCID, Zhang Shuting1, Chen Xuan1, Lu Wangwang4, Liu Wei13
Affiliation:
1. College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China 2. College of Materials Science and Engineering, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing 211816, China 3. National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan 430075, China 4. Guangzhou Jiyan Cosmetics Technology Co., Ltd., Guangzhou 510275, China
Abstract
Due to the stratum corneum barrier, resveratrol is difficult to be absorbed transdermally, limiting its anti-aging and skin-brightening effects. Furthermore, there is a lack of systematic studies on the efficacy of resveratrol in human skin, especially in three-dimensional skin models and clinical trials. To overcome the low transdermal delivery issue, we encapsulated resveratrol into nanoliposomes using the high-pressure homogenization method to develop an efficient transdermal drug delivery system, and systematically evaluated its anti-aging and skin-brightening efficacy via cell line models, a three-dimensional skin model and human skin. The resveratrol nanoliposomes effectively improved the transdermal penetration and retention of resveratrol and enhanced cellular uptake. In addition, compared to free resveratrol, resveratrol nanoliposomes remarkably enhanced the skin-care effects by promoting the antioxidant capacity and collagen synthesis, inhibiting the secretion of matrix metalloproteinases, tyrosine activity and melanin synthesis. Notably, human clinical trials proved the anti-wrinkle and skin-brightening effectiveness of resveratrol nanoliposomes. Three levels of systematic studies indicated that resveratrol nanoliposomes could be a promising transdermal drug delivery system to enhance the anti-aging and skin-brightening effects of resveratrol.
Funder
National Natural Science Foundation of China National Key R & D Program of Nanotechnology of China Nanjing Overseas Students Merit-Based Program Funding
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference49 articles.
1. Health benefits of resveratrol: Evidence from clinical studies;Singh;Med. Res. Rev.,2019 2. Anti-tumor effects and cellular mechanisms of resveratrol;Han;Drug Discov. Ther.,2015 3. Antibacterial and antifungal properties of resveratrol;Vestergaard;Int. J. Antimicrob. Agents,2019 4. Jia, Y., Shao, J.-H., Zhang, K.-W., Zou, M.-L., Teng, Y.-Y., Tian, F., Chen, M.-N., Chen, W.-W., Yuan, Z.-D., and Wu, J.-J. (2022). Emerging effects of resveratrol on wound healing: A Comprehensive Review. Molecules, 27. 5. Na, J.-I., Shin, J.-W., Choi, H.-R., Kwon, S.-H., and Park, K.-C. (2019). Resveratrol as a multifunctional topical hypopigmenting agent. Int. J. Mol. Sci., 20.
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