Insights into the Protective Effects of Thymoquinone against Toxicities Induced by Chemotherapeutic Agents

Author:

Farooq JuveriyaORCID,Sultana Rokeya,Taj Tahreen,Asdaq Syed Mohammed BasheeruddinORCID,Alsalman Abdulkhaliq J.,Mohaini Mohammed AlORCID,Al Hawaj Maitham A.,Kamal MehnazORCID,Alghamdi SaadORCID,Imran Mohd.ORCID,Shahin HaleemaORCID,Tabassum RuheenaORCID

Abstract

The drugs used to treat cancer not only kill fast-growing cancer cells, but also kill or slow the growth of healthy cells, causing systemic toxicities that lead to altered functioning of normal cells. Most chemotherapeutic agents have serious toxicities associated with their use, necessitating extreme caution and attention. There is a growing interest in herbal remedies because of their pharmacological activities, minimal side effects, and low cost. Thymoquinone, a major component of the volatile oil of Nigella sativa Linn, also known as black cumin or black seeds, is commonly used in Middle Eastern countries as a condiment. It is also utilized for medicinal purposes and possesses antidiabetic, anti-cancer, anti-inflammatory, hepatoprotective, anti-microbial, immunomodulatory, and antioxidant properties. This review attempts to compile the published literature demonstrating thymoquinone’s protective effect against chemotherapeutic drug-induced toxicities.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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