Two New Compounds from the Endophytic Fungi of Dryopteris crassirhizoma and Their Antimicrobial Activities

Author:

Hai Ping12,Gao Yuan2,Yang Lian1,Chen Nie2,Jia Haiyan2,Wang Mengdie2,Li Huan2,Jiang Wenli2,Yang Jian3,Li Rongtao1

Affiliation:

1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China

2. Faculty of Materials and Chemical Engineering, Yibin University, Yibin 644000, China

3. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medical, China Academy of Chinese Medical Sciences, Beijing 100010, China

Abstract

Two endophytic fungi Trichoderma afroharzianum (HP-3) and Alternaria alstroemeriae (HP-7) were isolated and purified from the fresh root of Dryopteris crassirhizoma. Chemical investigation of the two fungi resulted in the isolation of two new phenols 2,4-dihydroxy-3-farnesyl-5-methoxy benzoic acid (1) and 2-hydroxyphenethyl 2-phenylacetate (2), together with 22 known compounds. Their structures were elucidated by NMR, UV, IR, HRESIMS, and comparison to the literature data. Compounds 15 and 16 showed significant antibacterial activity against Micrococcus lysodeikticus with MIC value of 6.25 μg/mL, while 8 and 14 displayed moderate inhibitory activities against several plant pathogenic fungi and clinically important bacterial strains. This is the first study to report the isolation, identification, and antimicrobial properties of metabolites from endophytic fungi of D. crassirhizoma. Our findings may provide lead compounds for the development of new antibacterial agents.

Funder

National Natural Science Foundation of China

The Yunnan Innovation Team

Higher Educational Key Laboratory for New drugs for Viral Respiratory Diseases (Chinese Traditional Medicine) of Yunnan Province

Chinese Medical Sciences

The Key Project at Central Government Level: the ability establishment of sustainable use for valuable Chinese medicine resources

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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