Analogy of the Reactions of Aromatic and Aliphatic π-Electrophiles with Nucleophiles-Reference-Cited by-同舟云学术

Analogy of the Reactions of Aromatic and Aliphatic π-Electrophiles with Nucleophiles

Published:2023-05-11 Issue:10 Volume:28 Page:4015
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Barbasiewicz Michał¹^ORCID,Fedoryński Michał²,Loska Rafał³^ORCID,Mąkosza Mieczysław³^ORCID

Affiliation:

1. Faculty of Chemistry, University of Warsaw, 02-093 Warsaw, Poland

2. Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland

3. Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

Abstract

The aim of this essay is to disclose the similarity of a great variety of reactions that proceed between nucleophiles and π-electrophiles—both aromatic and aliphatic. These reactions proceed via initial reversible addition, followed by a variety of transformations that are common for the adducts of both aliphatic and aromatic electrophiles. We hope that understanding of this analogy should help to expand the scope of the known reactions and inspire the search for new reactions that were overlooked.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/10/4015/pdf

Reference106 articles.

1. Introduction of Carbon Substituents into Nitroarenes via Nucleophilic Substitution of Hydrogen: New Developments;Loska;Synthesis,2020

2. Reaction of Nucleophiles with Nitroarenes—Multifacial and Versatile Electrophile;Chem. Eur. J.,2014

3. Nucleophilic Substitution of Hydrogen in Electron-Deficient Arenes, a General Process of Great Practical Value;Chem. Soc. Rev.,2010

4. Terrier, F. (2013). Modern Nucleophilic Aromatic Substitution, Wiley-VCH.

5. Concerted Nucleophilic Aromatic Substitution Reactions;Rohrbach;Angew. Chem. Int. Ed.,2019