Research Progress on Effects of Ginsenoside Rg2 and Rh1 on Nervous System and Related Mechanisms
-
Published:2023-12-04
Issue:23
Volume:28
Page:7935
-
ISSN:1420-3049
-
Container-title:Molecules
-
language:en
-
Short-container-title:Molecules
Author:
Liu Silu1, Chen Weijia1, Zhao Yan1, Zong Ying1, Li Jianming12, He Zhongmei1
Affiliation:
1. College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China 2. Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118, China
Abstract
Neurological-related disorders are diseases that affect the body’s neurons or peripheral nerve tissue, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). The development of neurological disorders can cause serious harm to the quality of life and functioning of the patient. The use of traditional therapeutic agents such as dopamine-promoting drugs, anticholinergic drugs, cholinesterase inhibitors, and NMDA receptor antagonists is often accompanied by a series of side effects such as drug resistance, cardiac arrhythmia, liver function abnormalities, and blurred vision. Therefore, there is an urgent need to find a therapeutic drug with a high safety profile and few side effects. Herbal medicines are rich in active ingredients that are natural macromolecules. Ginsenoside is the main active ingredient of ginseng, which has a variety of pharmacological effects and is considered to have potential value in the treatment of human diseases. Modern pharmacological studies have shown that ginsenosides Rg2 and Rh1 have strong pharmacological activities in the nervous system, with protective effects on nerve cells, improved resistance to neuronal injury, modulation of neural activity, resistance to cerebral ischemia/reperfusion injury, improvement of brain damage after eclampsia hemorrhage, improvement of memory and cognitive deficits, treatment of AD and vascular dementia, alleviation of anxiety, pain, and inhibition of ionic-like behavior. In this article, we searched the pharmacological research literature of Rg2 and Rh1 in the field of neurological diseases, summarized the latest research progress of the two ginsenosides, and reviewed the pharmacological effects and mechanisms of Rg2 and Rh1, which provided a new way of thinking for the research of the active ingredients in ginseng anti-neurological diseases and the development of new drugs.
Funder
Major Science and Technology Project of Jilin Province—Major Science and Technology Innovation Project of Sika Deer Industry Special Assistance Project of Jilin Province to Xinjiang Uygur Autonomous Region
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference125 articles.
1. Yin and Yang of ginseng pharmacology: Ginsenosides vs. gintonin;Im;Acta Pharmacol. Sin.,2013 2. Characterization of the Components and Pharmacological Effects of Mountain-Cultivated Ginseng and Garden Ginseng Based on the Integrative Pharmacology Strategy;Li;Front. Pharmacol.,2021 3. Ginsenosides in Panax genus and their biosynthesis;Hou;Acta Pharm. Sin. B,2021 4. Piao, X., Zhang, H., Kang, J.P., Yang, D.U., Li, Y., Pang, S., Jin, Y., Yang, D., and Wang, Y. (2020). Advances in Saponin Diversity of Panax ginseng. Molecules, 25. 5. Zang, H. (2016). Study on the Preparation Method of Primary Panaxtriol Secondary Ginsenosides and Sapogenin. [Master’s Thesis, Jilin University].
|
|