A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor-Reference-Cited by-同舟云学术

A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor

Published:2023-11-02 Issue:21 Volume:28 Page:7391
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Lv Xueyan¹,Lv Lili²,Li Shichen¹,Ding Chengcheng¹,Yang Bingchuan³,Ma Chen¹

Affiliation:

1. Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China

2. China Petroleum Planning and Engineering Institute, Dongying 257237, China

3. College of Chemistry and Chemical Engineering, Qilu Normal University, Jinan 250013, China

Abstract

An iodine-mediated one-pot synthesis of pyrrolo/indolo [1,2-a]quinoxalines and quinazolin-4-one via utilizing epoxides as alkyl precursors under metal-free conditions has been described. Both 1-(2-aminophenyl)-pyrrole and 2-aminobenzamide could be applied to this protocol. A total of 33 desired products were obtained with moderate to good yields. This methodology was suitable for wide-scale preparation and the obtained products could be further modified into promising pharmaceutically active reagents.

Funder

Shandong Key Research Program

Zhejiang Xin’an Chemical Group Company Basic Research Project

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/21/7391/pdf

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