On Water Arrangements in Right- and Left-Handed DNA Structures-Reference-Cited by-同舟云学术

On Water Arrangements in Right- and Left-Handed DNA Structures

Published:2024-01-19 Issue:2 Volume:29 Page:505
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Yatsunyk Liliya A.¹^ORCID,Neidle Stephen²^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USA

2. UCL School of Pharmacy, University College London, London WC1N 1AX, UK

Abstract

DNA requires hydration to maintain its structural integrity. Crystallographic analyses have enabled patterns of water arrangements to be visualized. We survey these water motifs in this review, focusing on left- and right-handed duplex and quadruplex DNAs, together with the i-motif. Common patterns of linear spines of water organization in grooves have been identified and are widely prevalent in right-handed duplexes and quadruplexes. By contrast, a left-handed quadruplex has a distinctive wheel of hydration populating the almost completely circular single groove in this structure.

Funder

National Institute of Health

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/29/2/505/pdf

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