Four New Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata and DFT-Based Structure Elucidation-Reference-Cited by-全球学者库

Four New Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata and DFT-Based Structure Elucidation

Published:2023-09-30 Issue:19 Volume:28 Page:6892
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Yu Dan-Dan¹,Ke Lin-Mao¹,Liu Jiao²,Li Song-Wei³^ORCID,Su Ming-Zhi⁴^ORCID,Yao Li-Gong²⁴,Luo Hui¹,Guo Yue-Wei²³⁴^ORCID

Affiliation:

1. College of Pharmacy, Guangdong Medical University, Zhanjiang 524023, China

2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

3. School of Medicine, Shanghai University, Shanghai 200444, China

4. Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China

Abstract

Three new cembranoids (1–3) and a new casbanoid (4), along with three known analogues (5–7), have been isolated from the soft coral Sinularia nanolobata collected off Ximao Island. The structures, including the absolute configurations of new compounds, were established using extensive spectroscopic data analysis, time-dependent density functional theory/electronic circular dichroism (TDDFT-ECD) calculations, and the comparison with spectroscopic data of known compounds. In the in vitro bioassay, compounds 1 and 5 exhibited moderate cytotoxic activities against human erythroleukemia (HEL) cell lines, with IC50 values of 37.1 and 42.4 μM, respectively.

Funder

National Science Foundation of China

National Key Research and Development Program of China

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/19/6892/pdf

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