Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
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Published:2024-09-04
Issue:17
Volume:29
Page:4193
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Nie Wenzhe1, Wang Yalan1, Tian Xinlu2, Liu Jinying1, Jin Zhanhui1, Xu Junjie1, He Miaohai1, Shen Qingkun1, Guo Hongyan1, Luan Tian2ORCID
Affiliation:
1. Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China 2. Department of Pharmacy, Shenyang Medical College, Shenyang 110034, China
Abstract
The emergence of natural products has provided extremely valuable references for the treatment of various diseases. Cucurbitacin B, a tetracyclic triterpenoid compound isolated from cucurbitaceae and other plants, is the most abundant member of the cucurbitin family and exhibits a wide range of biological activities, including anti-inflammatory, anti-cancer, and even agricultural applications. Due to its high toxicity and narrow therapeutic window, structural modification and dosage form development are necessary to address these issues with cucurbitacin B. This paper reviews recent research progress in the pharmacological action, structural modification, and application of cucurbitacin B. This review aims to enhance understanding of advancements in this field and provide constructive suggestions for further research on cucurbitacin B.
Funder
National Natural Science Foundation of China Jilin Province Science and technology Department key research and development project Jilin Provincial Scientific Technological Development Program Scientific Research Project of the Department of Education of Liaoning Province Shenyang Medical College student research project
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