Abstract
Molecular recognition involving glycoprotein-mediated interactions is ubiquitous in both normal and pathological natural processes. Therefore, visualization of these interactions and the extent of expression of the sugars is a challenge in medical diagnosis, monitoring of therapy, and drug design. Here, we review the literature on the development and validation of probes for magnetic resonance imaging using carbohydrates either as targeting vectors or as a target. Lectins are important targeting vectors for carbohydrate end groups, whereas selectins, the asialoglycoprotein receptor, sialic acid end groups, hyaluronic acid, and glycated serum and hemoglobin are interesting carbohydrate targets.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference210 articles.
1. Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., Mohnen, D., Kinoshita, T., Packer, N.H., and Prestegard, J.H. (2022). Essentials of Glycobiology, Cold Spring Harbor Laboratory Press. [4th ed.].
2. Atwood, J.L. (2017). Comprehensive Supramolecular Chemistry II, Elsevier.
3. Polysaccharide-based theranostic systems for combined imaging and cancer therapy: Recent advances and challenges;Gupta;ACS Biomater. Sci. Eng.,2022
4. Machado, V., Morais, M., and Medeiros, R. (2022). Hyaluronic acid-based nanomaterials applied to cancer: Where are we now?. Pharmaceutics, 14.
5. Advances in hyaluronic acid for biomedical applications;Yasin;Front. Bioeng. Biotechnol.,2022
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献