Affiliation:
1. TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
Abstract
Norditerpenes are considered to be a common and widely studied class of bioactive compounds in plants, exhibiting a wide array of complex and diverse structural types and originating from various sources. Based on the number of carbons, norditerpenes can be categorized into C19, C18, C17, and C16 compounds. Up to now, 557 norditerpenes and their derivatives have been found in studies published between 2010 and 2023, distributed in 51 families and 132 species, with the largest number in Lamiaceae, Euphorbiaceae, and Cephalotaxaceae. These norditerpenes display versatile biological activities, including anti-tumor, anti-inflammatory, antimicrobial, and antioxidant properties, as well as inhibitory effects against HIV and α-glucosidase, and can be considered as an important source of treatment for a variety of diseases that had a high commercial value. This review provides a comprehensive summary of the plant sources, chemical structures, and biological activities of norditerpenes derived from natural sources, serving as a valuable reference for further research development and application in this field.
Funder
National Natural Science Foundation of China
Ungraduated Students Research Innovative Program of Hunan University of Chinese Medicine
Key Research and Development Programs of Hunan Science and Technology Department
Research Foundation of Education Bureau of Hunan Province
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference174 articles.
1. Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids;Shen;Nat. Prod. Rep.,2020
2. Penioxalicin, a novel 3-nor-2,3-seco-labdane type diterpene from the fungus Penicillium oxalicum TW01-1;Bian;Tetrahedron Lett.,2015
3. Penitholabene, a rare 19-nor labdane-type diterpenoid from the deep-sea-derived fungus Penicillium thomii YPGA3;Li;Fitoterapia,2020
4. Bioactive terpenoids from Euonymus verrucosus var;Yang;pauciflorus showing no inhibitory activities. Bioorg. Chem.,2019
5. Terpenoids from Chloranthus serratus and their anti-inflammatory activities;Zhang;J. Nat. Prod.,2012