Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti-Reference-Cited by-同舟云学术

Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti

Published:2023-07-25 Issue:15 Volume:28 Page:5639
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

De Vita Daniela¹,Frezza Claudio¹^ORCID,Sciubba Fabio¹²^ORCID,Toniolo Chiara¹,Badiali Camilla¹^ORCID,Petrucci Rita³^ORCID,Bortolami Martina³^ORCID,Di Matteo Paola³^ORCID,Rocco Daniele³,Stringaro Annarita⁴^ORCID,Colone Marisa⁴^ORCID,Maxia Andrea⁵^ORCID,Petrucci Maria Teresa⁶^ORCID,Serafini Mauro¹,Foddai Sebastiano¹

Affiliation:

1. Department of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy

2. NMR-Based Metabolomics Laboratory, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy

3. Department of Basic and Applied Sciences for Engineering, “Sapienza” University of Rome, Via Castro Laurenziano 7, 00161 Rome, Italy

4. National Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy

5. Laboratory of Economic and Pharmaceutical Botany, Department of Life and Environmental Sciences, University of Cagliari, Viale S. Ignazio da Laconi 13, 09123 Cagliari, Italy

6. Department of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome, Via Benevento 6, 00161 Rome, Italy

Abstract

Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/15/5639/pdf

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