Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury-Reference-Cited by-同舟云学术

Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury

Published:2023-10-31 Issue:21 Volume:28 Page:7359
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Andrianov Viacheslav V.¹²,Kulchitsky Vladimir A.³,Yafarova Guzel G.¹²,Bazan Leah V.¹,Bogodvid Tatiana K.²⁴,Deryabina Irina B.²,Muranova Lyudmila N.²,Silantyeva Dinara I.²,Arslanov Almaz I.²,Paveliev Mikhail N.⁵,Fedorova Ekaterina V.³,Filipovich Tatiana A.³,Nagibov Aleksei V.³,Gainutdinov Khalil L.¹²

Affiliation:

1. Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia

2. Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia

3. Brain Center, Institute of Physiology, National Academy of Sciences, 220012 Minsk, Belarus

4. Department of Biomedical Sciences, Volga Region State University of Physical Culture, Sport and Tourism, 420000 Kazan, Russia

5. Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland

Abstract

Nitric oxide (NO) production in injured and intact brain regions was compared by EPR spectroscopy in a model of brain and spinal cord injury in Wistar rats. The precentral gyrus of the brain was injured, followed by the spinal cord at the level of the first lumbar vertebra. Seven days after brain injury, a reduction in NO content of 84% in injured brain regions and 66% in intact brain regions was found. The difference in NO production in injured and uninjured brain regions persisted 7 days after injury. The copper content in the brain remained unchanged one week after modeling of brain and spinal cord injury. The data obtained in the experiments help to explain the problems in the therapy of patients with combined brain injury.

Funder

Belarusian Republican Foundation for Basic Research

RSF

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/21/7359/pdf

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