Isolation and Structure Elucidation of New Metabolites from the Mariana-Trench-Associated Fungus Aspergillus sp. SY2601-Reference-Cited by-同舟云学术

Isolation and Structure Elucidation of New Metabolites from the Mariana-Trench-Associated Fungus Aspergillus sp. SY2601

Published:2024-01-17 Issue:2 Volume:29 Page:459
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Sun Cangzhu¹,Ha Yura¹^ORCID,Liu Xin¹,Wang Nan¹²,Lian Xiao-Yuan³,Zhang Zhizhen¹^ORCID

Affiliation:

1. Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China

2. Hainan Institute of Zhejiang University, Sanya 572025, China

3. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

Abstract

Fungi are important resource for the discovery of novel bioactive natural products. This study investigated the metabolites produced by Mariana-Trench-associated fungus Aspergillus sp. SY2601 in EY liquid and rice solid media, resulting in the isolation and structure determination of 28 metabolites, including five new compounds, asperindopiperazines A–C (1–3), 5-methoxy-8,9-dihydroxy-8,9-deoxyaspyrone (21), and 12S-aspertetranone D (26). Structures of the new compounds were elucidated based on extensive NMR spectral analyses, HRESIMS data, optical rotation, ECD, and 13C NMR calculations. The new compound 12S-aspertetranone D (26) exhibited antibacterial activity against both methicillin-resistant Staphylococcus aureus and Escherichia coli with MIC values of 3.75 and 5 μg/mL, respectively.

Funder

Basic Public Welfare Research Project of Zhejiang Province

Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City

National Key R&D Program of China

National Natural Science Foundation of China

HPC Center of Zhejiang University

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/29/2/459/pdf

Reference42 articles.

1. Secondary metabolites of fungi from marine habitats;Rateb;Nat. Prod. Rep.,2011

2. Major bioactive metabolites from marine fungi: A Review;Hasan;Bioinformation,2015

3. New natural products from the marine-derived Aspergillus fungi—A review;Zhao;Acta Microbilogica Sin.,2016

4. New bioactive metabolites from the marine-derived fungi Aspergillus;Wang;Mini. Rev. Med. Chem.,2018

5. Recent updates on the bioactive compounds of the marine-derived genus Aspergillus;Orfali;RSC Adv.,2021