Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action-Reference-Cited by-同舟云学术

Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action

Published:2023-03-02 Issue:5 Volume:28 Page:2306
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Mirza Fatima Javed¹²,Zahid Saadia²^ORCID,Holsinger R. M. Damian¹³^ORCID

Affiliation:

1. Laboratory of Molecular Neuroscience and Dementia, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia

2. Neurobiology Research Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad 44000, Pakistan

3. Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia

Abstract

Carnosic acid is a diterpenoid abundantly present in plants belonging to the genus Rosmarinus and Salvia of the family Lamiaceae, accounting for their application in traditional medicine. The diverse biological properties of carnosic acid that include antioxidant, anti-inflammatory, and anticarcinogenic activities have instigated studies on its mechanistic role, providing further insights into its potential as a therapeutic agent. Accumulating evidence has established the relevance of carnosic acid as a neuroprotective agent exhibiting therapeutic efficacy in combatting neuronal-injury-induced disorders. The physiological importance of carnosic acid in the mitigation of neurodegenerative disorders is just beginning to be understood. This review summarizes the current data on the mode of action through which carnosic acid exerts its neuroprotective role that may serve to strategize novel therapeutic approaches for these debilitating neurodegenerative disorders.

Funder

Higher Education Commission of Pakistan

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/5/2306/pdf

Reference91 articles.

1. Carnosic acid;Birtic;Phytochemistry,2015

2. Rašković, A., Milanovic, I., Pavlovic, N., Cebovic, T., Vukmirovic, S., and Mikov, M. (2014). Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential. BMC Complement. Altern. Med., 14.

3. Antioxidant activities of rosemary (Rosmarinus officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol;Erkan;Food Chem.,2008

4. Taram, F., Ignowski, E., Duval, N., and Linseman, D.A. (2018). Neuroprotection Comparison of Rosmarinic Acid and Carnosic Acid in Primary Cultures of Cerebellar Granule Neurons. Molecules, 23.

5. Subcellular compartmentation of the diterpene carnosic acid and its derivatives in the leaves of rosemary;Alegre;Plant Physiol.,2001

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The function of carnosic acid in lipopolysaccharides-induced hepatic and intestinal inflammation in poultry;Poultry Science;2024-03

2. Carnosic Acid Shows Higher Neuroprotective Efficiency than Edaravone or Ebselen in In Vitro Models of Neuronal Cell Damage;Molecules;2023-12-24

3. Emerging Role of Plant-Based Bioactive Compounds as Therapeutics in Parkinson’s Disease;Molecules;2023-11-14

4. Carnosic Acid and Carnosol: Analytical Methods for Their Determination in Plants, Foods and Biological Samples;Separations;2023-09-02

5. The Use of Ultrasound-Assisted Maceration for the Extraction of Carnosic Acid and Carnosol from Sage (Salvia officinalis L.) Directly into Fish Oil;Molecules;2023-08-16