Chlorine in an Organic Molecule, a Universal Promoter—Workhorse—Of Reactions-Reference-Cited by-同舟云学术

Chlorine in an Organic Molecule, a Universal Promoter—Workhorse—Of Reactions

Published:2023-12-05 Issue:24 Volume:28 Page:7957
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Mąkosza Mieczysław¹,Fedoryński Michał²

Affiliation:

1. Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

2. Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland

Abstract

Due to the electronic configuration of the atom and charge of the nucleus, the chlorine in organic molecules can exert a variety of effects. It can depart as a chloride anion in the process of substitution and elimination, facilitates the abstraction of protons and stabilizes generated carbanions, exerts moderate stabilizing effect of carbenes, carbocations and radicals. There are frequent cases where chlorine substituent promotes more than one transformation. These rich effects of chlorine substituent will be illustrated by examples of our work.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/24/7957/pdf

Reference75 articles.

1. Catalysis in Two-Phase Systems. Phase Transfer and Related Phenomena;Adv. Catal.,1987

2. Dehmlow, E.V., and Dehmlow, S.S. (1993). Phase Transfer Catalysis, VCH. [3rd ed.].

3. Starks, C.M., Liotta, C.L., and Halpern, M. (1994). Phase Transfer Catalysis. Fundamentals, Applications and Industrial Perspectives, Chapman & Hall.

4. Two-phase reactions in organic chemistry;Scott;Survey of Progress in Chemistry,1980

5. Jones, R.A. (2001). Quaternary Ammonium Salts: Their Use in Phase Transfer Catalysis, Academic Press.