New Approved Drugs Appearing in the Pharmaceutical Market in 2022 Featuring Fragments of Tailor-Made Amino Acids and Fluorine-Reference-Cited by-同舟云学术

New Approved Drugs Appearing in the Pharmaceutical Market in 2022 Featuring Fragments of Tailor-Made Amino Acids and Fluorine

Published:2023-04-22 Issue:9 Volume:28 Page:3651
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Wang Nana¹,Mei Haibo¹,Dhawan Gagan²³⁴^ORCID,Zhang Wei⁵^ORCID,Han Jianlin¹^ORCID,Soloshonok Vadim A.⁶⁷^ORCID

Affiliation:

1. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

2. School of Allied Medical Sciences, Delhi Skill and Entrepreneurship University, Dwarka, New Delhi 110075, India

3. Department of Biomedical Science, Acharya Narendra Dev College, University of Delhi, Kalkaji, New Delhi 110019, India

4. Delhi School of Skill Enhancement and Entrepreneurship Development, Institution of Eminence, University of Delhi, Delhi 110007, India

5. Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA

6. Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain

7. IKERBASQUE, Basque Foundation for Science, Alameda Urquijo 36-5, 48011 Bilbao, Spain

Abstract

The strategic fluorination of oxidatively vulnerable sites in bioactive compounds is a relatively recent, widely used approach allowing us to modulate the stability, bio-absorption, and overall efficiency of pharmaceutical drugs. On the other hand, natural and tailor-made amino acids are traditionally used as basic scaffolds for the development of bioactive molecules. The main goal of this review article is to emphasize these general trends featured in recently approved pharmaceutical drugs.

Funder

National Natural Science Foundation of China

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/9/3651/pdf

Reference132 articles.

1. Tailor-Made Amino Acids and Fluorinated Motifs as Prominent Traits in the Modern Pharmaceuticals;Mei;Chem. Eur. J.,2020

2. Wang, Q., Han, J., Sorochinsky, A., Landa, A., Butler, G., and Soloshonok, V.A. (2022). The Latest FDA-Approved Pharmaceuticals Containing Fragments of Tailor-Made Amino Acids and Fluorine. Pharmaceuticals, 15.

3. New prodrug approach for amino acids and amino-acid-like drugs;Eur. J. Med. Chem.,1996

4. Unusual amino acids in medicinal chemistry;Blaskovich;J. Med. Chem.,2016

5. The current state of peptide drug discovery: Back to the future?;Henninot;J. Med. Chem.,2018

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Copper-catalyzed multicomponent reaction of β-trifluoromethyl β-diazo esters enabling the synthesis of β-trifluoromethyl N,N-diacyl-β-amino esters;Beilstein Journal of Organic Chemistry;2024-02-02

2. Iron-catalyzed sulfur alkylation of sulfenamides with in situ-generated 2,2,2-trifluorodiazoethane;Journal of Fluorine Chemistry;2024-01

3. Asymmetric Metal‐Templated Approach to Amino Acids with a CF₃‐Containing 3,2’‐Pyrrolidinyl Spirooxindole Core via a Michael/Mannich [3+2]‐Cycloaddition Reaction;Advanced Synthesis & Catalysis;2023-12-21

4. Monofluoromethylation of N-Heterocyclic Compounds;International Journal of Molecular Sciences;2023-12-18

5. Synthesis of trifluoromethyl formazans by reaction of trifluoromethyl N-acylhydrazones/N-Aryl hydrazones and aryldiazonium tetrafluoroborates;Journal of Fluorine Chemistry;2023-11