Research Progress Regarding the Effect and Mechanism of Dietary Polyphenols in Liver Fibrosis

Author:

Chang Jiayin1,Huang Congying1,Li Siqi1,Jiang Xiaolei1,Chang Hong1,Li Minhui123ORCID

Affiliation:

1. Department of Pharmacy, Baotou Medical College, Baotou 014040, China

2. Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot 010020, China

3. Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Baotou 014040, China

Abstract

The development of liver fibrosis is a result of chronic liver injuries may progress to liver cirrhosis and liver cancer. In recent years, liver fibrosis has become a major global problem, and the incidence rate and mortality are increasing year by year. However, there are currently no approved treatments. Research on anti-liver-fibrosis drugs is a top priority. Dietary polyphenols, such as plant secondary metabolites, have remarkable abilities to reduce lipid metabolism, insulin resistance and inflammation, and are attracting more and more attention as potential drugs for the treatment of liver diseases. Gradually, dietary polyphenols are becoming the focus for providing an improvement in the treatment of liver fibrosis. The impact of dietary polyphenols on the composition of intestinal microbiota and the subsequent production of intestinal microbial metabolites has been observed to indirectly modulate signaling pathways in the liver, thereby exerting regulatory effects on liver disease. In conclusion, there is evidence that dietary polyphenols can be therapeutically useful in preventing and treating liver fibrosis, and we highlight new perspectives and key questions for future drug development.

Funder

National Natural Science Foundation of China

Inner Mongolia Natural Science Foundation Project

Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region

Inner Mongolia Autonomous Region Chinese Medicine (Mongolian Medicine) Young and Middle-aged Leading Talents Cultivation Project

“Innovation Team Development Plan” of Colleges and Universities in Inner Mongolia Autonomous Region

Alxa League Science and Technology Program

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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