Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities
-
Published:2023-10-28
Issue:21
Volume:28
Page:7321
-
ISSN:1420-3049
-
Container-title:Molecules
-
language:en
-
Short-container-title:Molecules
Author:
Yu Ruirui1, Li Xiaojian1, Yi Peng12, Wen Ping3, Wang Shuhong3, Liao Chenghui4, Song Xun2ORCID, Wu Haiqiang1, He Zhendan12ORCID, Li Chenyang1ORCID
Affiliation:
1. School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China 2. College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China 3. Shenzhen Institute for Drug Control, Shenzhen 518057, China 4. School of Pharmacy, Harbin Medical University, Harbin 150081, China
Abstract
This study explores the antifungal properties of Agaricus blazei Murrill, a valuable medicinal and edible fungus. Six compounds (1–6) were first isolated from A. blazei using various isolation techniques and identified using spectroscopic methods. These compounds include linoleic acid, 1,1′-oxybis(2,4-di-tert-butylbenzene), glycerol monolinoleate, volemolide (17R)-17-methylincisterol, (24s)-ergosta-7-en-3-ol, and dibutyl phthalate. This study also assesses the antifungal activities of these compounds against Trichophyton mentagrophology, Trichophyton rubrum, Candida albicans, and Cryptococcus neoformans. The results demonstrate varied sensitivities against these pathogenic fungi, with compound 2 showing significant inhibition against T. mentagrophology, compound 3 showing significant inhibition against T. rubrum, and compound 6 showing significant inhibition against C. albicans. This study underscores the medicinal potential of A. blazei as an antifungal agent and sheds light on its valuable research implications.
Funder
Shenzhen Natural Science Fund Shenzhen Science and Technology Innovation Committee Guangdong Basic and Applied Basic Research Foundation National Natural Science Foundation of China
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference43 articles.
1. Pérez-Gómez, L., Pérez-Martínez, A.T., Matheeussen, A., Pieters, L., Mendez, D., Quirós-Molina, Y., Trujillo, R., Tuenter, E., and Cos, P. (2023). Phytochemical characterization and antifungal potential of leaf extracts of Mosiera bullata. Nat. Prod. Res., 1–10. 2. Exploration of Remarkably Potential Multitarget-Directed N-Alkylated-2-(substituted phenyl)-1-benzimidazole Derivatives as Antiproliferative, Antifungal, and Antibacterial Agents;Phan;ACS Omega,2023 3. Critical review on chemical compositions and health-promoting effects of mushroom Agaricus blazei Murill;Huang;Curr. Res. Food Sci.,2022 4. Extraction, Characterization, and In Vitro Hypoglycemic Activity of a Neutral Polysaccharide from the New Medicinal Mushroom Cantharellus yunnanensis (Agaricomycetes);Pan;Int. J. Med. Mushrooms,2023 5. Chemical constituents from Ilex hainanensis;Peng;Zhong Yao Cai,2012
|
|