Abstract
Opioids are used to treat pain, but despite their effectiveness, they possess several side effects such as respiratory depression, tolerance and physical dependence. Cebranopadol has been evaluated as a solution to this problem. The compound acts on the mu opioid receptor and the nociceptin/orphanin receptor and these receptors co-activation can reduce opioid side-effects without compromising analgesia. In the present review, we have compiled information on the effects of cebranopadol, its pharmacokinetics, and clinical trials involving cebranopadol, to further explore its promise in pain management.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference41 articles.
1. Zespoły uzależnień od substancji psychoaktywnych;Baran-Furga,2012
2. A Review of Potential Adverse Effects of Long-Term Opioid Therapy
3. Adverse effects of chronic opioid therapy for chronic musculoskeletal pain. Nature reviews;Crofford;Rheumatology,2010
4. Separation of Morphine Analgesia from Physical Dependence
5. Exploring the opioid system by gene knockout
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献