Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities (II)-Reference-Cited by-全球学者库

Monoterpenoid Glycosides from the Leaves of Ligustrum robustum and Their Bioactivities (II)

Published:2023-10-26 Issue:21 Volume:28 Page:7274
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Lu Shi-Hui¹²³^ORCID,Li Xiu-Xia⁴,Zuo Hao-Jiang⁵^ORCID,Li Wei-Neng¹,Pan Jia-Ping¹,Huang Jing⁶

Affiliation:

1. College of Pharmacy, Youjiang Medical University for Nationalities, Baise 533000, China

2. Guangxi Database Construction and Application Engineering Research Center for in Tracorporal Pharmacochemistry of TCM, Baise 533000, China

3. Key Laboratory of Youjiang Basin Characteristic Ethnic Medicine Research in Guangxi, Baise 533000, China

4. Nursing School, Youjiang Medical University for Nationalities, Baise 533000, China

5. Department of Laboratory Science of Public Health, West China School of Public Health, Sichuan University, Chengdu 610041, China

6. Key Laboratory of Drug Targeting, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Abstract

Ligustrum robustum has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of L. robustum, ten new monoterpenoid glycosides named ligurobustosides T10 (1a), T11 (1b), T12 (2a), T13 (2b), T14 (3a), T15 (3b), F1 (4b), T16 (5a), T17 (5b), and E1 (6b), together with five known ones (4a, 6a, 7, 8a, 8b), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound 5 (IC50: 4.38 ± 0.11 μM) was as strong as orlistat (IC50: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds 1–4 and 7–8, and the α-amylase inhibitory actions of compounds 1–8 were medium; the ABTS radical scavenging capacities of compounds 1–3 and 5–8 (IC50: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than l-(+)-ascorbic acid (IC50: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of L. robustum to prevent diabetes and its complications.

Funder

Guangxi Natural Science Foundation Project

Guangxi Science and Technology Base and Talents Special Project

Youjiang Medical University for Nationalities Science Research Project

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/21/7274/pdf

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