Purification, Structural Analysis and Cardio-Protective Activity of Polysaccharides from Radix Astragali

Author:

Wang Shilei1,Peng Yuan2,Zhuang Yixin2,Wang Nan1,Jin Jianchang1,Zhan Zhajun2

Affiliation:

1. College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China

2. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China

Abstract

Two polysaccharides, named APS2-I and APS3-I, were purified from the water extract of Radix Astragali. The average molecular weight of APS2-I was 1.96 × 106 Da and composed of Man, Rha, GlcA, GalA, Glc, Gal, Xyl, and Ara in a molar ratio of 2.3:4.8:1.7:14.0:5.8:11.7:2.8:12.6, while the average molecular weight of APS3-I was 3.91 × 106 Da and composed of Rha, GalA, Glc, Gal, and Ara in a molar ratio of 0.8:2.3:0.8:2.3:4.1. Biological evaluation showed APS2-I and APS3-I had significant antioxidant activity and myocardial protection activity. Furthermore, total polysaccharide treatment could significantly enhance hemodynamic parameters and improve cardiac function in rat ischemia and reperfusion isolated heart models. These results provided important information for the clinical application of APS in the field of cardiovascular disease and implied that Astragalus polysaccharides (APS) could be considered as a reference for the quality control of Radix Astragali.

Funder

Zhejiang Provincial Natural Science Foundation of China

National Natural Science Foundation of China

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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