Application of Chitosan-Based Hydrogel in Promoting Wound Healing: A Review
Author:
Che Xueyan1, Zhao Ting1, Hu Jing1, Yang Kaicheng1, Ma Nan1, Li Anning2, Sun Qi3, Ding Chuanbo1, Ding Qiteng4
Affiliation:
1. College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology University, Jilin City 132101, China 2. Jilin Aodong Yanbian Pharmaceutical Co., Ltd., Dunhua 133000, China 3. Jilin Zhengrong Pharmaceutical Development Co., Ltd., Dunhua 133700, China 4. College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118, China
Abstract
Chitosan is a linear polyelectrolyte with active hydroxyl and amino groups that can be made into chitosan-based hydrogels by different cross-linking methods. Chitosan-based hydrogels also have a three-dimensional network of hydrogels, which can accommodate a large number of aqueous solvents and biofluids. CS, as an ideal drug-carrying material, can effectively encapsulate and protect drugs and has the advantages of being nontoxic, biocompatible, and biodegradable. These advantages make it an ideal material for the preparation of functional hydrogels that can act as wound dressings for skin injuries. This review reports the role of chitosan-based hydrogels in promoting skin repair in the context of the mechanisms involved in skin injury repair. Chitosan-based hydrogels were found to promote skin repair at different process stages. Various functional chitosan-based hydrogels are also discussed.
Funder
Jilin Provincial Department of Education
Subject
Polymers and Plastics,General Chemistry
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