EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma-Reference-Cited by-全球学者库

EBV-Associated Hub Genes as Potential Biomarkers for Predicting the Prognosis of Nasopharyngeal Carcinoma

Published:2023-09-12 Issue:9 Volume:15 Page:1915
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Ding Tengteng¹²,Zhang Yuanbin¹²,Ren Zhixuan³,Cong Ying¹²,Long Jingyi²⁴,Peng Manli¹²,Faleti Oluwasijibomi Damola²⁴,Yang Yinggui¹⁵^ORCID,Li Xin¹²,Lyu Xiaoming²⁴^ORCID

Affiliation:

1. Shenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre (CIRC), Shenzhen Hospital of Southern Medical University, Shenzhen 518100, China

2. The Third School of Clinical Medicine, Southern Medical University, Guangzhou 510630, China

3. Department of Radiation Oncology, Huadong Hospital, Fudan University, Shanghai 200040, China

4. Department of Laboratory Medicine, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, China

5. Department of Urology, Shenzhen Hospital of Southern Medical University, Shenzhen 518100, China

Abstract

This study aimed to develop a model using Epstein–Barr virus (EBV)-associated hub genes in order to predict the prognosis of nasopharyngeal carcinoma (NPC). Differential expression analysis, univariate regression analysis, and machine learning were performed in three microarray datasets (GSE2371, GSE12452, and GSE102349) collected from the GEO database. Three hundred and sixty-six EBV-DEGs were identified, 25 of which were found to be significantly associated with NPC prognosis. These 25 genes were used to classify NPC into two subtypes, and six genes (C16orf54, CD27, CD53, CRIP1, RARRES3, and TBC1D10C) were found to be hub genes in NPC related to immune infiltration and cell cycle regulation. It was shown that these genes could be used to predict the prognosis of NPC, with functions related to tumor proliferation and immune infiltration, making them potential therapeutic targets. The findings of this study could aid in the development of screening and prognostic methods for NPC based on EBV-related features.

Funder

Guangdong Basic and Applied Basic Research Foundation, China

President Foundation of the Third Affiliated Hospital, Southern Medical University

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

Link

https://www.mdpi.com/1999-4915/15/9/1915/pdf

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