Emetine in Combination with Chloroquine Induces Oncolytic Potential of HIV-1-Based Lentiviral Particles

Author:

Spirin PavelORCID,Shyrokova ElenaORCID,Vedernikova Valeria,Lebedev Timofey,Prassolov Vladimir

Abstract

Chloroquine and Emetine are drugs used to treat human parasitic infections. In addition, it has been shown that these drugs have an antiviral effect. Both drugs were also found to cause a suppressive effect on the growth of cancer cells of different origins. Here, using the replication-deficient HIV-1-based lentiviral vector particles, we evaluated the ability of the combination of these drugs to reduce viral transduction efficiency. We showed that these drugs act synergistically to decrease cancer cell growth when added in combination with medium containing lentiviral particles. We found that the combination of these drugs with lentiviral particles decreases the viability of treated cells. Taken together, we state the oncolytic potential of the medium containing HIV-1-based particles provoked by the combination of Chloroquine and Emetine.

Funder

Russian Science Foundation

Russian Foundation for Basic Research

Ministry of Science and Higher Education of the Russian Federation

Publisher

MDPI AG

Subject

General Medicine

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