Microemulsion-Based Keratin–Chitosan Gel for Improvement of Skin Permeation/Retention and Activity of Curcumin
Author:
Niu Jiangxiu1, Yuan Ming1, Gao Panpan1, Wang Liye1, Qi Yueheng1, Chen Jingjing1, Bai Kaiyue1, Fan Yanli1, Liu Xianming1
Affiliation:
1. College of Food and Drug, Luoyang Normal University, Luoyang 471934, China
Abstract
Curcumin (Cur) is a kind of polyphenol with a variety of topical pharmacological properties including antioxidant, analgesic and anti-inflammatory activities. However, its low water solubility and poor skin bioavailability limit its effectiveness. In the current study, we aimed to develop microemulsion-based keratin–chitosan gel for the improvement of the topical activity of Cur. The curcumin-loaded microemulsion (CME) was formulated and then loaded into the keratin–chitosan (KCS) gel to form the CME-KCS gel. The formulated CME-KCS gel was evaluated for its characterization, in vitro release, in vitro skin permeation and in vivo activity. The results showed that the developed CME-KCS gel had an orange-yellow and gel-like appearance. The particle size and zeta potential of the CME-KCS gel were 186.45 ± 0.75 nm and 9.42 ± 0.86 mV, respectively. The CME-KCS gel showed desirable viscoelasticity, spreadability, bioadhesion and controlled drug release, which was suitable for topical application. The in vitro skin permeation and retention study showed that the CME-KCS gel had better in vitro skin penetration than the Cur solution and achieved maximum skin drug retention (3.75 ± 0.24 μg/cm2). In vivo experimental results confirmed that the CME-KCS gel was more effective than curcumin-loaded microemulsion (Cur-ME) in analgesic and anti-inflammatory activities. In addition, the CME-KCS gel did not cause any erythema or edema based on a mice skin irritation test. These findings indicated that the developed CME-KCS gel could improve the skin penetration and retention of Cur and could become a promising formulation for topical delivery to treat local diseases.
Funder
Key Scientific Research Project of Higher Education of Henan Province national project cultivation fund of Luoyang Normal University key scientific and technological project of Henan of China innovative training program for college students in Henan Province of China
Subject
Polymers and Plastics,Organic Chemistry,Biomaterials,Bioengineering
Reference62 articles.
1. Basto, R., Andrade, R., Nunes, C., Lima, S.A.C., and Reis, S. (2021). Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect. Pharmaceutics, 13. 2. Nanovesicular transferosomes for the topical delivery of plant bioactives;Sahu;Nanomedicine,2021 3. Malik, M.R., Al-Harbi, F.F., Nawaz, A., Amin, A., Farid, A., Mohaini, M.A., Alsalman, A.J., Hawaj, M.A.A., and Alhashem, Y.N. (2022). Formulation and Characterization of Chitosan-Decorated Multiple Nanoemulsion for Topical Delivery In Vitro and Ex Vivo. Molecules, 27. 4. Application of Cellular Resolution Full-Field Optical Coherence Tomography in vivo for the Diagnosis of Skin Tumours and Inflammatory Skin Diseases: A Pilot Study;Wang;Dermatology,2022 5. Curcumin Loaded Ethosomal Gel for Improved Topical Delivery: Formulation, Characterization and Ex-vivo Studies;Kumar;Pharm. Nanotechnol.,2021
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