1. Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, UK
2. Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne NE1 7RU, UK
3. Cardiology Department, John Radcliffe Hospital, Oxford OX3 9DU, UK
4. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
5. Cardiology Department, Hammersmith Hospital, Imperial College London, London W12 0HS, UK