Ultra-High Sensitivity Terahertz Microstructured Fiber Biosensor for Diabetes Mellitus and Coronary Heart Disease Marker Detection
Author:
Xue Jia1, Zhang Yani1, Guang Zhe2, Miao Ting1, Ali Zohaib23, Qiao Dun4, Yao Yiming1, Wu Kexin1, Zhou Lei5, Meng Cheng5, Copner Nigel4
Affiliation:
1. Department of Physics, School of Arts & Sciences, Shaanxi University of Science & Technology, Xi’an 710021, China 2. School of Physics, Georgia Institute of Technology, 837 State Street NW, Atlanta, GA 30332, USA 3. Nano-Optoelectronics Research Laboratory, Department of Physics, University of Agriculture Faisalabad, Faisalabad 38040, Pakistan 4. Faculty of Computing, Engineering and Science, University of South Wales, Pontypridd CF37 1DL, UK 5. School of Electrical and Control Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China
Abstract
Diabetes Mellitus (DM) and Coronary Heart Disease (CHD) are among top causes of patient health issues and fatalities in many countries. At present, terahertz biosensors have been widely used to detect chronic diseases because of their accurate detection, fast operation, flexible design and easy fabrication. In this paper, a Zeonex-based microstructured fiber (MSF) biosensor is proposed for detecting DM and CHD markers by adopting a terahertz time-domain spectroscopy system. A suspended hollow-core structure with a square core and a hexagonal cladding is used, which enhances the interaction of terahertz waves with targeted markers and reduces the loss. This work focuses on simulating the transmission performance of the proposed MSF sensor by using a finite element method and incorporating a perfectly matched layer as the absorption boundary. The simulation results show that this MSF biosensor exhibits an ultra-high relative sensitivity, especially up to 100.35% at 2.2THz, when detecting DM and CHD markers. Furthermore, for different concentrations of disease markers, the MSF exhibits significant differences in effective material loss, which can effectively improve clinical diagnostic accuracy and clearly distinguish the extent of the disease. This MSF biosensor is simple to fabricate by 3D printing and extrusion technologies, and is expected to provide a convenient and capable tool for rapid biomedical diagnosis.
Funder
Key Science and Technology Program of Shaanxi Province China Scholarship Council Science and Technology project of Xi’an City Natural Science Basic Research Program of Shaanxi Province Scientific Research Plan Project of Shaanxi Education Department Special Foundation of Shaanxi Provincial Department of Education
Subject
Electrical and Electronic Engineering,Biochemistry,Instrumentation,Atomic and Molecular Physics, and Optics,Analytical Chemistry
Reference46 articles.
1. Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., and Wei, P. (2020). Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments. Front Endocrinol, 11. 2. Lykina, A.A., Nazarov, M.M., Konnikova, M.R., Mustafin, I.A., Vaks, V.L., and Anfertev, V.A. (2021). Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets. J. Biomed. Opt., 26. 3. Khan, R.M.M., Chua, Z.J.Y., Tan, J.C., Yang, Y., Liao, Z., and Zhao, Y. (2019). From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research. Medicina, 55. 4. Wang, D., Zhang, Y., Han, J., Li, X., Chen, X., Qiu, T., and Chen, H. (2021). Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy. Sci. Rep., 11. 5. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study;Roth;J. Am. Coll. Cardiol.,2020
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|