Abstract
Yellow fever virus (YFV) is a mosquito-borne flavivirus circulating throughout the tropical and sub-tropical regions of Africa and South America. It is responsible for an estimated 30,000 deaths annually, and while there is a highly successful vaccine, coverage is incomplete, and there is no approved treatment for YFV infection. Despite advancements in the field, animal models for YFV infection remain scarce, and care must be taken to select an appropriate model for a given hypothesis. Small animal models require either adapted YFV strains or immunocompromised hosts. Non-human primates (NHPs) recapitulate human disease, but they require specialized facilities and training, are often in short supply and cost-prohibitive, and can present ethical concerns. The limitations in studying the mosquito vectors for YFV infection include inconsistency in the laboratory environment, the requirement for a high containment insectary, and difficulty in maintaining sylvatic mosquitoes. In this review, we discuss the roles of animal models and arthropod vector studies in understanding epidemic emergence.
Funder
National Institutes of Health
UTMB Center for Vector-borne and Zoonotic Diseases
Subject
Virology,Microbiology (medical),Microbiology
Reference86 articles.
1. ICTV Virus Taxonomy Profile: Flaviviridae
2. Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
3. Fever versus fever: The role of host and vector susceptibility and interspecific competition in shaping the current and future distributions of the sylvatic cycles of dengue virus and yellow fever virus
4. Angola: Epidemic (Yellow Fever) Emergency Plan of Action Preliminary Final Report (MDRAO006)—Angola|ReliefWebhttps://reliefweb.int/report/angola/angola-epidemic-yellow-fever-emergency-plan-action-preliminary-final-report-mdrao006
5. Recent advances in research regarding sylvatic yellow fever in West and Central Africa;Germain;Bull. De L’institut Pasteur,1982
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献