Abstract
Coronaviruses belong to a large family of viruses that can cause disease outbreaks ranging from the common cold to acute respiratory syndrome. Since 2003, three zoonotic members of this family evolved to cross species barriers infecting humans and resulting in relatively high case fatality rates (CFR). Compared to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV, CFR = 10%) and pandemic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, CFR = 6%), the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has scored the highest CFR (approximately 35%). In this review, we systematically summarize the current state of scientific knowledge about MERS-CoV, including virology and origin, epidemiology, zoonotic mode of transmission, and potential therapeutic or prophylactic intervention modalities.
Funder
National Institutes of Health
Subject
Virology,Microbiology (medical),Microbiology
Reference166 articles.
1. A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae
2. ICTV Taxonomy History for Coronavirinae Virus Taxonomy: 2011 Releasehttp://www.ictvonline.org/virusTaxonomy.asp?taxnode_id=20110624
3. Coronaviruses post-SARS: update on replication and pathogenesis
4. Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
5. MERS-CoV Situation Updatehttp://www.fao.org/ag/againfo/programmes/en/empres/mers/situation_update.html
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