Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets
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Published:2023-03-05
Issue:5
Volume:24
Page:4992
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Qin Xiaofeng1, Ning Yujie1, Zhou Liming1, Zhu Youming1
Affiliation:
1. Key Laboratory of Oral Diseases Research of Anhui Province, Department of Dental Implant Center, Stomatologic Hospital and College, Anhui Medical University, Hefei 230032, China
Abstract
Oral submucosal fibrosis (OSF) is a chronic, progressive and potentially malignant oral disorder with a high regional incidence and malignant rate. With the development of the disease, the normal oral function and social life of patients are seriously affected. This review mainly introduces the various pathogenic factors and mechanisms of OSF, the mechanism of malignant transformation into oral squamous cell carcinoma (OSCC), and the existing treatment methods and new therapeutic targets and drugs. This paper summarizes the key molecules in the pathogenic and malignant mechanism of OSF, the miRNAs and lncRNAs with abnormal changes, and the natural compounds with therapeutic effects, which provides new molecular targets and further research directions for the prevention and treatment of OSF.
Funder
National Natural Science Foundation of China Research Level Improvement Plan of Anhui Medical University
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference114 articles.
1. Chen, P.Y., Chao, S.C., Hsieh, P.L., Liao, Y.W., Chu, P.M., Harn, H.J., and Yu, C.C. (2022). Butylidenephthalide Abrogates the Snail-Induced Cancer Stemness in Oral Carcinomas. Int. J. Mol. Sci., 23. 2. Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue;Muller;Head Neck Pathol.,2022 3. Oral submucous fibrosis: A global challenge. Rising incidence, risk factors, management, and research priorities;Ray;Periodontol. 2000,2019 4. A contemporary narrative review to guide molecular epidemiology of oral submucous fibrosis;Singh;Int. J. Mol. Epidemiol. Genet.,2021 5. Cirillo, N., Duong, P.H., Er, W.T., Do, C.T.N., De Silva, M.E.H., Dong, Y., Cheong, S.C., Sari, E.F., McCullough, M.J., and Zhang, P. (2022). Are There Betel Quid Mixtures Less Harmful than Others? A Scoping Review of the Association between Different Betel Quid Ingredients and the Risk of Oral Submucous Fibrosis. Biomolecules, 12.
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