The Role of NLRP3, a Star of Excellence in Myeloproliferative Neoplasms-Reference-Cited by-同舟云学术

The Role of NLRP3, a Star of Excellence in Myeloproliferative Neoplasms

Published:2023-03-02 Issue:5 Volume:24 Page:4860
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Parciante Elisa¹,Cumbo Cosimo¹^ORCID,Anelli Luisa¹,Zagaria Antonella¹,Redavid Immacolata¹,Minervini Angela¹,Conserva Maria Rosa¹,Tota Giuseppina¹,Coccaro Nicoletta¹^ORCID,Tarantini Francesco¹^ORCID,Minervini Crescenzio Francesco¹^ORCID,Macchia Maria Giovanna¹,Specchia Giorgina²,Musto Pellegrino¹^ORCID,Albano Francesco¹^ORCID

Affiliation:

1. Hematology Section, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari ‘Aldo Moro’, 70124 Bari, Italy

2. School of Medicine, University of Bari ‘Aldo Moro’, 70124 Bari, Italy

Abstract

Nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) is the most widely investigated inflammasome member whose overactivation can be a driver of several carcinomas. It is activated in response to different signals and plays an important role in metabolic disorders and inflammatory and autoimmune diseases. NLRP3 belongs to the pattern recognition receptors (PRRs) family, expressed in numerous immune cells, and it plays its primary function in myeloid cells. NLRP3 has a crucial role in myeloproliferative neoplasms (MPNs), considered to be the diseases best studied in the inflammasome context. The investigation of the NLRP3 inflammasome complex is a new horizon to explore, and inhibiting IL-1β or NLRP3 could be a helpful cancer-related therapeutic strategy to improve the existing protocols.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/5/4860/pdf

Reference127 articles.

1. Myelodysplastic Syndromes: The Complexity of Stem-Cell Diseases;Corey;Nat. Rev. Cancer,2007

2. Acute Myeloid Leukemia;Longo;N. Engl. J. Med.,2015

3. Myeloproliferative Neoplasms: A Contemporary Review;Tefferi;JAMA Oncol.,2015

4. Chronic Inflammation as a Promotor of Mutagenesis in Essential Thrombocythemia, Polycythemia Vera and Myelofibrosis. A Human Inflammation Model for Cancer Development?;Hasselbalch;Leuk. Res.,2013

5. Complexity of Bone Marrow Hematopoietic Stem Cell Niche;Asada;Int. J. Hematol.,2017

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