Affiliation:
1. Department of Pharmacology and Toxicology, University of Navarra, 31008 Pamplona, Spain
2. IdISNA, Navarra Institute for Health Research, 31008 Pamplona, Spain
Abstract
Alzheimer’s disease (AD) is the main type of dementia and is a disease with a profound socioeconomic burden due to the lack of effective treatment. In addition to genetics and environmental factors, AD is highly associated with metabolic syndrome, defined as the combination of hypertension, hyperlipidemia, obesity and type 2 diabetes mellitus (T2DM). Among these risk factors, the connection between AD and T2DM has been deeply studied. It has been suggested that the mechanism linking both conditions is insulin resistance. Insulin is an important hormone that regulates not only peripheral energy homeostasis but also brain functions, such as cognition. Insulin desensitization, therefore, could impact normal brain function increasing the risk of developing neurodegenerative disorders in later life. Paradoxically, it has been demonstrated that decreased neuronal insulin signalling can also have a protective role in aging and protein-aggregation-associated diseases, as is the case in AD. This controversy is fed by studies focused on neuronal insulin signalling. However, the role of insulin action on other brain cell types, such as astrocytes, is still unexplored. Therefore, it is worthwhile exploring the involvement of the astrocytic insulin receptor in cognition, as well as in the onset and/or development of AD.
Funder
Spanish Ministry of Science and Innovation Competitiveness
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference199 articles.
1. Alzheimer’s Disease;Ballard;Lancet,2011
2. Meta-Review of CSF Core Biomarkers in Alzheimer’s Disease: The State-of-the-Art after the New Revised Diagnostic Criteria;Ferreira;Front. Aging Neurosci.,2014
3. Alzheimer Association (2022). 2022 Alzheimer’s Disease Facts and Figures. Alzheimers Dement., 18, 700–789.
4. Role of Glutamate and NMDA Receptors in Alzheimer’s Disease;Wang;J. Alzheimers Dis.,2017
5. Kuns, B., Rosani, A., and Varghese, D. (2022). StatPearls, StatPearls Publishing.
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