Specificity Proteins (SP) and Krüppel-like Factors (KLF) in Liver Physiology and Pathology

Author:

Yerra Veera Ganesh1,Drosatos Konstantinos1ORCID

Affiliation:

1. Metabolic Biology Laboratory, Cardiovascular Center, Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA

Abstract

The liver acts as a central hub that controls several essential physiological processes ranging from metabolism to detoxification of xenobiotics. At the cellular level, these pleiotropic functions are facilitated through transcriptional regulation in hepatocytes. Defects in hepatocyte function and its transcriptional regulatory mechanisms have a detrimental influence on liver function leading to the development of hepatic diseases. In recent years, increased intake of alcohol and western diet also resulted in a significantly increasing number of people predisposed to the incidence of hepatic diseases. Liver diseases constitute one of the serious contributors to global deaths, constituting the cause of approximately two million deaths worldwide. Understanding hepatocyte transcriptional mechanisms and gene regulation is essential to delineate pathophysiology during disease progression. The current review summarizes the contribution of a family of zinc finger family transcription factors, named specificity protein (SP) and Krüppel-like factors (KLF), in physiological hepatocyte functions, as well as how they are involved in the onset and development of hepatic diseases.

Funder

National Heart, Lung, and Blood Institute

National Institute for General Medical Sciences

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference214 articles.

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3. A cell-type-resolved liver proteome;Ding;Mol. Cell. Proteom.,2016

4. Lautt, W.W. (2009). Colloquium Series on Integrated Systems Physiology: From Molecule to Function, Morgan & Claypool Publishers.

5. Flux, Impact, and Fate of Halogenated Xenobiotic Compounds in the Gut;Atashgahi;Front. Physiol.,2018

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