HIV/Tuberculosis Coinfection in Pregnancy and the Postpartum Period

Author:

Yilma Addis1,Bailey Hannah1,Karakousis Petros C.12,Karanika Styliani1ORCID

Affiliation:

1. Center for Tuberculosis Research, Division of Infectious Diseases, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 212875, USA

2. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA

Abstract

The convergence of Human Immunodeficiency Virus (HIV) and tuberculosis (TB) represents a considerable global public health challenge. The concurrent infection of HIV and TB in pregnant women not only intensifies the transmission of HIV from mother to fetus but also engenders adverse outcomes for maternal health, pregnancy, and infant well-being, necessitating the implementation of integrated strategies to effectively address and manage both diseases. In this article, we review the pathophysiology, clinical presentation, treatment, and management of HIV/TB coinfection during pregnancy, the postpartum period, and lactation and highlight the differences compared to the general population.

Publisher

MDPI AG

Subject

General Medicine

Reference133 articles.

1. The National Acadamy of Science Engineering, and Medicine, Health and Medicine Division, Board on Global Health, and Committee on Global Health and the Future of the United States (2017). Addressing Continous Threats: HIV/AIDS, Tuberculosis, and Malaria, National Academies Press (US).

2. HIV-TB Coinfection among 57 Million Pregnant Women, Obstetric Complications, Alcohol Use, Drug Abuse, and Depression;Fernandez;J. Pregnancy,2018

3. Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection;Bell;Nat. Rev. Genet.,2017

4. WHO (2020). Tuberculosis, World Health Organization. Available online: https://www.who.int/news-room/fact-sheets/detail/tuberculosis.

5. (2023, July 22). Estimated Percentage of Pregnant Women Living with HIV Who Received Antiretrovirals for Preventing Mother-to-Child Transmission. September 2022. Available online: https://www.who.int/data/gho/data/indicators/indicator-details/GHO/estimated-percentage-of-pregnant-women-living-with-hiv-who-received-antiretrovirals-for-preventing-mother-to-child-transmission.

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