Parathyroid Retrospective Analysis of Neoplasms Incidence (pTRANI Study): An Italian Multicenter Study on Parathyroid Carcinoma and Atypical Parathyroid Tumour-Reference-Cited by-同舟云学术

Parathyroid Retrospective Analysis of Neoplasms Incidence (pTRANI Study): An Italian Multicenter Study on Parathyroid Carcinoma and Atypical Parathyroid Tumour

Published:2023-09-29 Issue:19 Volume:12 Page:6297
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Gurrado Angela¹^ORCID,Pasculli Alessandro¹^ORCID,Avenia Nicola²,Bellantone Rocco³,Boniardi Marco⁴,Merante Boschin Isabella⁵,Calò Pietro Giorgio⁶^ORCID,Camandona Michele⁷,Cavallaro Giuseppe⁸^ORCID,Cianchi Fabio⁹^ORCID,Conzo Giovanni¹⁰,D’Andrea Vito¹¹,De Crea Carmela¹²¹³,De Pasquale Loredana¹⁴,Del Rio Paolo¹⁵^ORCID,Di Meo Giovanna¹^ORCID,Dionigi Gianlorenzo¹⁶¹⁷,Dobrinja Chiara¹⁸,Docimo Giovanni¹⁹,Famà Fausto²⁰^ORCID,Galimberti Attilio²¹,Giacomelli Laura²²^ORCID,Graceffa Giuseppa²³,Iacobone Maurizio⁵^ORCID,Innaro Nadia²⁴,Lombardi Celestino Pio³,Materazzi Gabriele²⁵,Medas Fabio⁶^ORCID,Mullineris Barbara²⁶,Oragano Luigi²⁷^ORCID,Palestini Nicola²⁸,Perigli Giuliano⁹^ORCID,Pezzolla Angela¹,Prete Francesco Paolo¹^ORCID,Raffaelli Marco¹²¹³^ORCID,Renzulli Giuseppina²⁹,Rosato Lodovico³⁰,Scerrino Gregorio²³,Sgaramella Lucia Ilaria¹^ORCID,Sorrenti Salvatore³¹^ORCID,Testini Carlotta⁹,Veroux Massimiliano³²^ORCID,Gasparri Guido⁷,Testini Mario¹^ORCID,pTRANI Study Group

Affiliation:

1. Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University Medical School of Bari, 70124 Bari, Italy

2. General and Endocrine Surgery Unit, S. Maria University Hospital, University of Perugia, 05100 Terni, Italy

3. Division of Endocrine and Metabolic Surgery, Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, Italy

4. General Oncology and Mini-Invasive Surgery Department, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy

5. Endocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, 35143 Padua, Italy

6. Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy

7. Department of Surgical Sciences, Molinette Hospital, University of Turin, 10126 Turin, Italy

8. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University, 00185 Rome, Italy

9. Digestive Surgery Unit, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy

10. Division of General, Oncological, Mini-Invasive and Obesity Surgery, Department of Medical and Traslational Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

11. Department of Surgical Sciences, Sapienza University, 00185 Rome, Italy

12. UOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, Italy

13. Centro di Ricerca in Chirurgia delle Ghiandole Endocrine e dell’Obesità, Università Cattolica del Sacro Cuore, 00168 Rome, Italy

14. Head and Neck Surgery Department, San Paolo Hospital, 20142 Milan, Italy

15. Department of General and Specialist Surgery, Parma University Hospital, University of Parma, 43126 Parma, Italy

16. Division of Surgery, Istituto Auxologico Italiano IRCCS, 20122 Milan, Italy

17. Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy

18. Department of Medical, Surgical and Health Sciences, University of Trieste, 34125 Trieste, Italy

19. Department of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, Italy

20. Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University Hospital “G. Martino”, 98125 Messina, Italy

21. Department of Surgery, Legnano Hospital, 20025 Legnano, Italy

22. Department of General and Speciality Surgery, Sapienza University, 00185 Rome, Italy

23. Department of Surgical Oncological and Oral Sciences, University of Palermo, 90127 Palermo, Italy

24. Unit of Endocrine Surgery, AOU “Dulbecco”, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy

25. Endocrine Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Area, University Hospital of Pisa, 56121 Pisa, Italy

26. Unit of General Surgery, Emergency and New Technologies, Modena Hospital, 41126 Modena, Italy

27. Surgical Unit of General Surgery, “San Biagio” Hospital, 28845 Domodossola, Italy

28. Candiolo Cancer Institute, Fondazione Piemontese per l’Oncologia, 10060 Candiolo, Italy

29. Unit of Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University Medical School of Bari, 70124 Bari, Italy

30. Department of Surgery-ASL TO4, Ivrea Hospital, 10015 Ivrea, Italy

31. Department of Surgery, Sapienza University, 00185 Rome, Italy

32. Department of Medical and Surgical Sciences and Advanced Technologies, University of Catania, 95100 Catania, Italy

Abstract

Background: Parathyroid cancer (PC) is a rare sporadic or hereditary malignancy whose histologic features were redefined with the 2022 WHO classification. A total of 24 Italian institutions designed this multicenter study to specify PC incidence, describe its clinical, functional, and imaging characteristics and improve its differentiation from the atypical parathyroid tumour (APT). Methods: All relevant information was collected about PC and APT patients treated between 2009 and 2021. Results: Among 8361 parathyroidectomies, 351 patients (mean age 59.0 ± 14.5; F = 210, 59.8%) were divided into the APT (n = 226, 2.8%) and PC group (n = 125, 1.5%). PC showed significantly higher rates (p < 0.05) of bone involvement, abdominal, and neurological symptoms than APT (48.8% vs. 35.0%, 17.6% vs. 7.1%, 13.6% vs. 5.3%, respectively). Ultrasound (US) diameter >3 cm (30.9% vs. 19.3%, p = 0.049) was significantly more common in the PC. A significantly higher frequency of local recurrences was observed in the PC (8.0% vs. 2.7%, p = 0.022). Mortality due to consequences of cancer or uncontrolled hyperparathyroidism was 3.3%. Conclusions: Symptomatic hyperparathyroidism, high PTH and albumin-corrected serum calcium values, and a US diameter >3 cm may be considered features differentiating PC from APT. 2022 WHO criteria did not impact the diagnosis.

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/2077-0383/12/19/6297/pdf

Reference50 articles.

1. Parathyroid cancer: An update;Rodrigo;Cancer Treat. Rev.,2020

2. Update on parathyroid carcinoma;Cetani;J. Endocrinol. Investig.,2016

3. Parathyroid carcinoma;Salcuni;Best. Pract. Res. Clin. Endocrinol. Metab.,2018

4. Parathyroid carcinoma in more than 1000 patients: A population-level analysis;Sadler;Surgery,2014

5. Molecular pathogenesis of parathyroid tumours;Cinque;Best. Pract. Res. Clin. Endocrinol. Metab.,2018

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Intraoperative parathyroid hormone monitoring in parathyroidectomy for hyperparathyroidism: a protocol for a network meta-analysis of diagnostic test accuracy;Frontiers in Surgery;2024-01-04

2. Management and surgical treatment of parathyroid carcinoma: a 6-year experience of a single centre of endocrine surgery unit;Frontiers in Endocrinology;2023-11-03