Influence of Various Strontium Formulations (Ranelate, Citrate, and Chloride) on Bone Mineral Density, Morphology, and Microarchitecture: A Comparative Study in an Ovariectomized Female Mouse Model of Osteoporosis-Reference-Cited by-同舟云学术

Influence of Various Strontium Formulations (Ranelate, Citrate, and Chloride) on Bone Mineral Density, Morphology, and Microarchitecture: A Comparative Study in an Ovariectomized Female Mouse Model of Osteoporosis

Published:2024-04-06 Issue:7 Volume:25 Page:4075
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Tomczyk-Warunek Agnieszka¹^ORCID,Turżańska Karolina²^ORCID,Posturzyńska Agnieszka²,Kowal Filip²,Blicharski Tomasz²^ORCID,Pano Inés Torné²,Winiarska-Mieczan Anna³^ORCID,Nikodem Anna⁴^ORCID,Dresler Sławomir⁵⁶^ORCID,Sowa Ireneusz⁵^ORCID,Wójciak Magdalena⁵^ORCID,Dobrowolski Piotr⁷^ORCID

Affiliation:

1. Laboratory of Locomotor Systems Research, Department of Rehabilitation and Physiotherapy, Medical University of Lublin, 20-954 Lublin, Poland

2. Department of Orthopaedics and Rehabilitation, Medical University of Lublin, 20-954 Lublin, Poland

3. Department of Bromatology and Nutrition Physiology, Institute of Animal Nutrition and Bromatology, University of Life Sciences in Lublin, Akademicka St. 13, 20-950 Lublin, Poland

4. Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego, 50-370 Wrocław, Poland

5. Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, Poland

6. Department of Plant Physiology and Biophysics, Institute of Biological Science, Maria Curie-Skłodowska University, 20-033 Lublin, Poland

7. Department of Functional Anatomy and Cytobiology, Maria Curie-Skłodowska University, 20-033 Lublin, Poland

Abstract

Osteoporosis stands out as a prevalent skeletal ailment, prompting exploration into potential treatments, including dietary strontium ion supplements. This study assessed the efficacy of supplementation of three strontium forms—strontium citrate (SrC), strontium ranelate (SrR), and strontium chloride (SrCl)—for enhancing bone structure in 50 female SWISS mice, aged seven weeks. In total, 40 mice underwent ovariectomy, while 10 underwent sham ovariectomy. Ovariectomized (OVX) mice were randomly assigned to the following groups: OVX (no supplementation), OVX + SrR, OVX + SrC, and OVX + SrCl, at concentrations equivalent to the molar amount of strontium. After 16 weeks, micro-CT examined trabeculae and cortical bones, and whole-bone strontium content was determined. Results confirm strontium administration increased bone tissue mineral density (TMD) and Sr content, with SrC exhibiting the weakest effect. Femur morphometry showed limited Sr impact, especially in the OVX + SrC group. This research highlights strontium’s potential in bone health, emphasizing variations in efficacy among its forms.

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/7/4075/pdf

Reference57 articles.

1. Molino, G., Montalbano, G., Pontremoli, C., Fiorilli, S., and Vitale-Brovarone, C. (2020). Imaging Techniques for the Assessment of the Bone Osteoporosis-Induced Variations with Particular Focus on Micro-CT Potential. Appl. Sci., 10.

2. An Overview and Management of Osteoporosis;Sozen;Eur. J. Rheumatol.,2017

3. Independent Predictors of All Osteoporosis-Related Fractures in Healthy Postmenopausal Women: The OFELY Study;Albrand;Bone,2003

4. Osteoporosis in the European Union: A Compendium of Country-Specific Reports;Svedbom;Arch. Osteoporos.,2013

5. (2019, December 10). Raport o Osteoporozie NFZ 2019. Available online: https://Glosseniora.Pl/2019/12/10/Raport-o-Zdrowiu-Narodowego-Funduszu-Zdrowia-Poswiecony-Osteoporozie.