Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays-Reference-Cited by-同舟云学术

Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays

Published:2023-11-07 Issue:11 Volume:11 Page:1694
ISSN:2076-393X
Container-title:Vaccines
language:en
Short-container-title:Vaccines

Author:

Saito Hiroaki¹²^ORCID,Yoshimura Hiroki¹³,Yoshida Makoto¹⁴,Tani Yuta⁵⁶^ORCID,Kawashima Moe¹,Uchiyama Taiga¹,Zhao Tianchen¹,Yamamoto Chika¹,Kobashi Yurie¹⁷,Sawano Toyoaki¹,Imoto Seiya⁸,Park Hyeongki⁹,Nakamura Naotoshi⁹,Iwami Shingo⁹,Kaneko Yudai¹⁰¹¹,Nakayama Aya¹²,Kodama Tatsuhiko¹¹,Wakui Masatoshi⁶,Kawamura Takeshi¹¹¹²,Tsubokura Masaharu¹²⁷¹³^ORCID

Affiliation:

1. Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima 960-1247, Japan

2. Department of Internal Medicine, Soma Central Hospital, Soma, Fukushima 976-0016, Japan

3. School of Medicine, Hiroshima University, Hiroshima, Hiroshima 739-8511, Japan

4. Faculty of Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo 173-8605, Japan

5. Medical Governance Research Institute, Minato-ku, Tokyo 108-0074, Japan

6. Department of Laboratory Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan

7. Department of Internal Medicine, Serireikai Group Hirata Central Hospital, Ishikawa County, Fukushima 963-8202, Japan

8. Division of Health Medical Intelligence, Human Genome Center, Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

9. Interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan

10. Medical & Biological Laboratories Co., Ltd., Minato-ku, Tokyo 105-0012, Japan

11. Laboratory for Systems Biology and Medicine, Research Centre for Advanced Science and Technology (RCAST), The University of Tokyo, Meguro-ku, Tokyo 153-8904, Japan

12. Isotope Science Centre, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan

13. Minamisoma Municipal General Hospital, Minamisoma, Fukushima 975-0033, Japan

Abstract

Although studies have demonstrated that infections with various viruses, bacteria, and parasites can modulate the immune system, no study has investigated changes in antibodies against microbial antigens after the COVID-19 mRNA vaccination. IgG antibodies against microbial antigens in the blood of vaccinees were comprehensively analyzed using microbial protein microarrays that carried approximately 5000 microbe-derived proteins. Changes in antibodies against microbial antigens were scrutinized in healthy participants enrolled in the Fukushima Vaccination Community Survey conducted in Fukushima Prefecture, Japan, after their second and third COVID-19 mRNA vaccinations. Antibody profiling of six groups stratified by antibody titer and the remaining neutralizing antibodies was also performed to study the dynamics of neutralizing antibodies against SARS-CoV-2 and the changes in antibodies against microbial antigens. The results showed that changes in antibodies against microbial antigens other than SARS-CoV-2 antigens were extremely limited after COVID-19 vaccination. In addition, antibodies against a staphylococcal complement inhibitor have been identified as microbial antigens that are associated with increased levels of neutralizing antibodies against SARS-CoV-2. These antibodies may be a predictor of the maintenance of neutralizing antibodies following the administration of a COVID-19 mRNA vaccine.

Funder

AMED

Medical & Biological Laboratories Co., Ltd.

Shenzhen YHLO Biotech Co., Ltd.

distributor and manufacturer of the antibody measurement system

Kowa Co. and the Research Center for Advanced Science and Technology at the University of Tokyo

Publisher

MDPI AG

Subject

Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology

Link

https://www.mdpi.com/2076-393X/11/11/1694/pdf

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