Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project-Reference-Cited by-全球学者库

Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project

Published:2023-09-26 Issue:10 Volume:11 Page:1527
ISSN:2076-393X
Container-title:Vaccines
language:en
Short-container-title:Vaccines

Author:

Leomanni Ludovica¹,Collatuzzo Giulia¹^ORCID,Sansone Emanuele²^ORCID,Sala Emma²^ORCID,De Palma Giuseppe²^ORCID,Porru Stefano³⁴^ORCID,Spiteri Gianluca⁴^ORCID,Monaco Maria Grazia Lourdes⁴^ORCID,Basso Daniela⁵⁶^ORCID,Pavanello Sofia⁷⁸^ORCID,Scapellato Maria Luisa⁷⁸,Larese Filon Francesca⁹^ORCID,Cegolon Luca⁹,Mauro Marcella⁹,Lodi Vittorio¹¹⁰,Lazzarotto Tiziana¹¹¹^ORCID,Noreña Ivan¹²,Reinkemeyer Christina¹²,Giang Le Thi Thu¹³^ORCID,Fabiánová Eleonóra¹⁴,Strhársky Jozef¹⁵,Dell’Omo Marco¹⁶,Murgia Nicola¹⁷,Carrasco-Ribelles Lucía A.¹⁸¹⁹²⁰²¹^ORCID,Violán Concepción¹⁸¹⁹²⁰²¹²²²³^ORCID,Mates Dana²⁴,Rascu Agripina²⁵,Vimercati Luigi²⁶^ORCID,De Maria Luigi²⁶^ORCID,Asafo Shuffield S.¹,Ditano Giorgia¹,Abedini Mahsa¹,Boffetta Paolo¹²⁷²⁸^ORCID

Affiliation:

1. Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy

2. Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25121 Brescia, Italy

3. Section of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, 37129 Verona, Italy

4. Clinical Unit of Occupational Medicine, University Hospital of Verona, 37100 Verona, Italy

5. Department of Medicine-DIMED, University of Padova, 35128 Padova, Italy

6. Laboratory Medicine Unit, University Hospital of Padova, 35128 Padova, Italy

7. Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy

8. Occupational Medicine Unit, University Hospital of Padova, 35128 Padova, Italy

9. Occupational Medicine Unit, Department of Medicine, Surgery and Health Sciences, University of Trieste, 34100 Trieste, Italy

10. SSD Health Surveillance, IRCCS University Hospital, 40139 Bologna, Italy

11. Microbiology Unit, IRCCS University Hospital, 40139 Bologna, Italy

12. Division of Infectious Diseases and Tropical Medicine, LMU University Hospital, 81377 Munich, Germany

13. Department of Pediatrics, Dr. von Hauner Children’s Hospital, LMU University Hospital, 81377 Munich, Germany

14. Occupational Health Department, Regional Authority of Public Health, 497556 Banská Bystrica, Slovakia

15. Medical Microbiology Department, Regional Authority of Public Health, 497556 Banská Bystrica, Slovakia

16. Unit of Occupational Medicine, Department on Medicine and Surgery, University of Perugia, 06125 Perugia, Italy

17. Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy

18. Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), 08303 Mataró, Spain

19. Direcció d’Atenció Primària Metropolitana Nord Institut Català de Salut, 08007 Barcelona, Spain

20. Grup de Recerca en Impacte de les Malalties Cròniques i les seves Trajectòries (GRIMTra), Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAPJGol), 08303 Barcelona, Spain

21. Network for Research on Chronicity, Primary Care and Health Promotion (RICAPPS), Instituto de Salud Carlos III, 28029 Madrid, Spain

22. Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain

23. Universitat Autónoma de Barcelona, 08193 Bellaterra, Spain

24. National Institute of Public Health, 050463 Bucharest, Romania

25. Department of Internal Medicine-Occupational Medicine, Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, Romania

26. Interdisciplinary Department of Medicine, University of Bari, 70121 Bari, Italy

27. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA

28. Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA

Abstract

Background: The effectiveness of the immunity provided by SARS-CoV-2 vaccines is an important public health issue. We analyzed the determinants of 12-month serology in a multicenter European cohort of vaccinated healthcare workers (HCW). Methods: We analyzed the sociodemographic characteristics and levels of anti-SARS-CoV-2 spike antibodies (IgG) in a cohort of 16,101 vaccinated HCW from eleven centers in Germany, Italy, Romania, Slovakia and Spain. Considering the skewness of the distribution, the serological levels were transformed using log or cubic standardization and normalized by dividing them by center-specific standard errors. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of one standard deviation of log or cubic antibody level and the corresponding 95% confidence interval (CI) for different factors and combined them in random-effects meta-analyses. Results: We included 16,101 HCW in the analysis. A high antibody level was positively associated with age (RR = 1.04, 95% CI = 1.00–1.08 per 10-year increase), previous infection (RR = 1.78, 95% CI 1.29–2.45) and use of Spikevax [Moderna] with combinations compared to Comirnaty [BioNTech/Pfizer] (RR = 1.07, 95% CI 0.97–1.19) and was negatively associated with the time since last vaccine (RR = 0.94, 95% CI 0.91–0.98 per 30-day increase). Conclusions: These results provide insight about vaccine-induced immunity to SARS-CoV-2, an analysis of its determinants and quantification of the antibody decay trend with time since vaccination.

Funder

EU Horizon 2020

Regional Health Authority (Azienda Zero), Veneto Region, Italy

Publisher

MDPI AG

Subject

Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology

Link

https://www.mdpi.com/2076-393X/11/10/1527/pdf

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