How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2-Reference-Cited by-同舟云学术

How European Research Projects Can Support Vaccination Strategies: The Case of the ORCHESTRA Project for SARS-CoV-2

Published:2023-08-14 Issue:8 Volume:11 Page:1361
ISSN:2076-393X
Container-title:Vaccines
language:en
Short-container-title:Vaccines

Author:

Azzini Anna Maria¹^ORCID,Canziani Lorenzo Maria¹^ORCID,Davis Ruth Joanna¹^ORCID,Mirandola Massimo¹^ORCID,Hoelscher Michael²³^ORCID,Meyer Laurence⁴,Laouénan Cédric⁵⁶,Giannella Maddalena⁷⁸,Rodríguez-Baño Jesús⁹¹⁰^ORCID,Boffetta Paolo⁸¹¹^ORCID,Mates Dana¹²,Malhotra-Kumar Surbhi¹³,Scipione Gabriella¹⁴^ORCID,Stellmach Caroline¹⁵^ORCID,Rinaldi Eugenia¹⁵,Hasenauer Jan¹⁶¹⁷,Tacconelli Evelina¹

Affiliation:

1. Infectious Diseases Division, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy

2. Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), 80802 Munich, Germany

3. German Center for Infection Research (DZIF), Partner Site Munich, 80802 Munich, Germany

4. Centre de Recherche en Epidemiologie et Sante des Population, Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris-Saclay, 94270 Le Kremlin-Bicêtre, France

5. INSERM, IAME UMR 1137, Universite Paris Cite, 75018 Paris, France

6. Departement d’Epidemiologie Biostatistiques e Recherche Clinique, AP-HP, Hospital Bichat, 75018 Paris, France

7. Infectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy

8. Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy

9. Infectious Diseases and Microbiology Unit, Hospital Universitario Virgen Macarena and Department of Medicine, Biomedicines Institute of Sevilla-CSIC, University of Sevilla, 41004 Sevilla, Spain

10. Centro de Investigacion Biomedica en Red en Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain

11. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 10041, USA

12. National Institute of Public Health, 050463 Bucharest, Romania

13. Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, 2000 Antwerp, Belgium

14. Supercomputing Applications and Innovation Department, Cineca Consorzio Interuniversitario, 40033 Bologna, Italy

15. Berlin Institute of Health at Charite, Universitätsmedizin Berlin, 10117 Berlin, Germany

16. Life and Medical Sciences Institute, University of Bonn, 53113 Bonn, Germany

17. Institute of Computational Biology, Helmholtz Center Munich—German Research Center for Environmental Health, 85764 Neuherberg, Germany

Abstract

ORCHESTRA (“Connecting European Cohorts to Increase Common and Effective Response To SARS-CoV-2 Pandemic”) is an EU-funded project which aims to help rapidly advance the knowledge related to the prevention of the SARS-CoV-2 infection and the management of COVID-19 and its long-term sequelae. Here, we describe the early results of this project, focusing on the strengths of multiple, international, historical and prospective cohort studies and highlighting those results which are of potential relevance for vaccination strategies, such as the necessity of a vaccine booster dose after a primary vaccination course in hematologic cancer patients and in solid organ transplant recipients to elicit a higher antibody titer, and the protective effect of vaccination on severe COVID-19 clinical manifestation and on the emergence of post-COVID-19 conditions. Valuable data regarding epidemiological variations, risk factors of SARS-CoV-2 infection and its sequelae, and vaccination efficacy in different subpopulations can support further defining public health vaccination policies.

Funder

European Union’s Horizon 2020

Publisher

MDPI AG

Subject

Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology

Link

https://www.mdpi.com/2076-393X/11/8/1361/pdf

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