Parsimonious Effect of Pentoxifylline on Angiogenesis: A Novel Pentoxifylline-Biased Adenosine G Protein-Coupled Receptor Signaling Platform

Author:

Khoury William1ORCID,Trus Ryan23,Chen Xingyu1,Baghaie Leili4ORCID,Clark Mira24,Szewczuk Myron R.4ORCID,El-Diasty Mohammad5ORCID

Affiliation:

1. School of Medicine, Queen’s University, Kingston, ON K7L 3L4, Canada

2. Faculty of Arts and Science, Queen’s University, Kingston, ON K7L 3N9, Canada

3. School of Medicine, The Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA

4. Department of Biomedical & Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada

5. Division of Cardiac Surgery, Queen’s University, Kingston, ON K7L 2V7, Canada

Abstract

Angiogenesis is the physiological process of developing new blood vessels to facilitate the delivery of oxygen and nutrients to meet the functional demands of growing tissues. It also plays a vital role in the development of neoplastic disorders. Pentoxifylline (PTX) is a vasoactive synthetic methyl xanthine derivative used for decades to manage chronic occlusive vascular disorders. Recently, it has been proposed that PTX might have an inhibitory effect on the angiogenesis process. Here, we reviewed the modulatory effects of PTX on angiogenesis and its potential benefits in the clinical setting. Twenty-two studies met the inclusion and exclusion criteria. While sixteen studies demonstrated that pentoxifylline had an antiangiogenic effect, four suggested it had a proangiogenic effect, and two other studies showed it did not affect angiogenesis. All studies were either in vivo animal studies or in vitro animal and human cell models. Our findings suggest that pentoxifylline may affect the angiogenic process in experimental models. However, there is insufficient evidence to establish its role as an anti-angiogenesis agent in the clinical setting. These gaps in our knowledge regarding how pentoxifylline is implicated in host-biased metabolically taxing angiogenic switch may be via its adenosine A2BAR G protein-coupled receptor (GPCR) mechanism. GPCR receptors reinforce the importance of research to understand the mechanistic action of these drugs on the body as promising metabolic candidates. The specific mechanisms and details of the effects of pentoxifylline on host metabolism and energy homeostasis remain to be elucidated.

Funder

Natural Sciences and Engineering Research Council of Canada

NSERC Alliance COVID19

Publisher

MDPI AG

Subject

General Medicine

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