The Multitasker Protein: A Look at the Multiple Capabilities of NUMB

Author:

Ortega-Campos Sara M.ORCID,García-Heredia José ManuelORCID

Abstract

NUMB, a plasma membrane-associated protein originally described in Drosophila, is involved in determining cell function and fate during early stages of development. It is secreted asymmetrically in dividing cells, with one daughter cell inheriting NUMB and the other inheriting its antagonist, NOTCH. NUMB has been proposed as a polarizing agent and has multiple functions, including endocytosis and serving as an adaptor in various cellular pathways such as NOTCH, Hedgehog, and the P53-MDM2 axis. Due to its role in maintaining cellular homeostasis, it has been suggested that NUMB may be involved in various human pathologies such as cancer and Alzheimer’s disease. Further research on NUMB could aid in understanding disease mechanisms and advancing the field of personalized medicine and the development of new therapies.

Publisher

MDPI AG

Subject

General Medicine

Reference211 articles.

1. Numb—From Flies to Humans;Yan;Brain Dev.,2010

2. The Multiple Functions of Numb;Gulino;Exp. Cell Res.,2010

3. The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization;Knoblich;Dev. Biol.,1997

4. Asymmetric Segregation of Numb and Prospero during Cell Division;Knoblich;Nature,1995

5. Asymmetric Distribution of Numb Protein during Division of the Sensory Organ Precursor Cell Confers Distinct Fates to Daughter Cells;Rhyu;Cell,1994

全球学者库

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"全球学者库"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前全球学者库共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2023 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3