Evaluating Gelatin-Based Films with Graphene Nanoparticles for Wound Healing Applications

Author:

Kamedulski Piotr12ORCID,Wekwejt Marcin3ORCID,Zasada Lidia4,Ronowska Anna5ORCID,Michno Anna5,Chmielniak Dorota4,Binkowski Paweł1,Łukaszewicz Jerzy P.12,Kaczmarek-Szczepańska Beata4ORCID

Affiliation:

1. Department of Materials Chemistry, Adsorption and Catalysis, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland

2. Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University in Torun, Wilenska 4, 87-100 Torun, Poland

3. Department of Biomaterials Technology, Faculty of Mechanical Engineering and Ship Technology, Gdańsk University of Technology, Gabriela Narutowicza 11/12, 80-229 Gdansk, Poland

4. Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland

5. Department of Laboratory Medicine, Medical University of Gdańsk, Marii Skłodowskiej-Curie 3a, 80-210 Gdansk, Poland

Abstract

In this study, gelatin-based films containing graphene nanoparticles were obtained. Nanoparticles were taken from four chosen commercial graphene nanoplatelets with different surface areas, such as 150 m2/g, 300 m2/g, 500 m2/g, and 750 m2/g, obtained in different conditions. Their morphology was observed using SEM with STEM mode; porosity, Raman spectra and elemental analysis were checked; and biological properties, such as hemolysis and cytotoxicity, were evaluated. Then, the selected biocompatible nanoparticles were used as the gelatin film modification with 10% concentration. As a result of solvent evaporation, homogeneous thin films were obtained. The surface’s properties, mechanical strength, antioxidant activity, and water vapor permeation rate were examined to select the appropriate film for biomedical applications. We found that the addition of graphene nanoplatelets had a significant effect on the properties of materials, improving surface roughness, surface free energy, antioxidant activity, tensile strength, and Young’s modulus. For the most favorable candidate for wound dressing applications, we chose a gelatin film containing nanoparticles with a surface area of 500 m2/g.

Publisher

MDPI AG

Subject

General Materials Science,General Chemical Engineering

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